1,720,968 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Epitheliaal ovarium carcinoma: moleculaire en klinische predictoren voor platinum resistentie
No full textMost patients with ovarian cancer are still diagnosed in advanced stage disease needing intensive therapy with debulking surgery and chemotherapy. However, 25 % of patients will progress during or will relapse within 6 months of the primary therapy. These patients are called the platinum resistant patients. Unfortunately there are not many therapeutic options for this group of patients available. This doctoral thesis was performed in an effort to identify platinum resistant patients at diagnosis by searching for molecular and clinical predictors for platinum resistance. In this way the burden of a cytotoxic therapy compromising bone marrow reserve and quality of life could be avoided and targets for more individualised therapy could be found. Proteins represent the actual functional molecules in a cell and when a mutation occurs at the DNA level, it is the protein that ultimately will be affected. Therefore the study of the proteome, meaning the entire protein content produced by a cell during its life cycle, can help us to detect changes occurring during a particular disease process. Challenges in proteomic studies in blood are the presence of high abundant proteins masking the detection of the low concentrated ones, inter- and intra-individual differences and the need for prospectively and well controlled collected samples. Therefore we took part in a European consortium, the OVCAD study, where biological samples of ovarian cancer patients were prospectively collected according to a strict protocol. In this way we were able to collect a substantial number of samples in a relative short study period. In an attempt to minimise variation in protein content and to improve the probability of finding an ovarian cancer specific marker we decided to perform proteomic analysis on tumor tissue biopsies. Moreover, as ovarian tumor tissue biopsies consist of a heterogeneous amount of cells, we preferred to work with laser microdissected ovarian cancer cells. In the molecular part of this thesis, we firstly identified current problems and obstacles in proteomic studies and subsequently defined a protocol to combine laser microdissection and SELDI-TOF MS analysis in ovarian cancer tissue to achieve robust protein profiles. We demonstrated that changes in sample handling have influences on the protein profile and that strict protocols are necessary to obtain reliable results.Using this protocol we performed a first analysis on LMD ovarian tumor tissue of platinum sensitive vs. resistant patients. Based on the obtained profiles we determined that CM10 and IMAC30 were the ProteinChip surfaces of interest to be used further SELDI-TOF MS analysis.This model was then applied on the prospectively collected OVCAD samples and a prediction model was build to classify patients according to platinum sensitivity. Furthermore, we were able to confirm differentially expressed peaks in the lower molecular mass range between platinum resistant and sensitive patients. One of the upregulated peaks in patients with platinum sensitive disease with an m/z value of 2885 Da, could be identified as Histone H2B type 1-D (H2B1D_Human). Histone modification is currently used in other cancers as target for therapy and this finding could therefore have a clinical impact and warrants further investigation. Subsequently a validation study was performed but was not able to confirm the results of the training set. We believe other techniques such as immunohistochemistry should be considered to establish the role of Histone H2B type 1-D in the predictions of platinum resistance in ovarian cancer. In the clinical part of this dissertation, we assessed the clinical data of patients included in the OVCAD study in relation to their platinum free interval to determine clinical predictors for response. After multivariate analysis we identified the presence of peritoneal carcinomatosis, high levels of CA125 at the end of therapy and the achievement of complete remission at the end of primary therapy as the most significant factors for platinum resistance. These data could guide us in the follow-up of EOC patients who are at risk for early relapse.In a next chapter we evaluated the effect of a dose dense or weekly paclitaxel carboplatinum regimen for recurrent ovarian cancer in an attempt to overcome platinum resistance. Both regimens achieved good RR of 37% in the platinum resistant group. Toxicity varied between both schemes but was acceptable. In conclusion the molecular studies in this thesis need further investigation and might have a clinical impact in the search for targeted therapy in resistant epithelial ovarian cancer. Secondly, in the clinical part we identified patients at risk for early recurrence and we suggest that even in platinum resistant patients a rechallenge with a modified paclitaxel and platinum containing regimen is a valuable treatment option.status: Publishe
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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