643 research outputs found
[University fellows]
No full textCommunications professor and holder of the Gocolay Distinguished Professorial Chair in Communication Arts Dr. Clodualdo del Mundo, Jr. and Biology professor, also the holder of the BPI Academic Chair from 1994-1998 Dr. Esperanza Cabrera are named University Fellows during the Faculty Recognition ceremonies
Synsepalum dulcificum extracts exhibit cytotoxic activity on human colorectal cancer cells and upregulate c-fos and c-jun early apoptotic gene expression
No full textObjective: To explore cytotoxicity of Synsepalum dulcificum (S. dulcificum) Daniell (Sapotaceae) on human colon cancer (HCT-116 and HT-29), human monocytic leukemia (THP-1) and normal (HDFn) cell lines, and its effect on the expression of early apoptotic genes, c-fos and c-jun. Methods: Leaf, stem and berry of S. dulcificum were separately extracted by using 2 solvents, 10% ethanol (EtOH) and 80% methanol (MeOH). PrestoBlue® cell viability assay and qRT-PCR assay were conducted to examine the above objectives respectively. Results: Stem MeOH, stem EtOH, and berry EtOH extracts of S. dulcificum were cytotoxic to HCT-116 and HT-29 human colon cancer cells. For HCT-116, IC50 values of these 3 extracts were not significantly different (P>0.05) from that of the positive control bleomycin (IC50 of 33.57 μg/mL), while for HT-29, IC50 values of these 3 extracts were significantly lower (P<0.05) than that of bleomycin (IC50 of 25.24 μg/mL). None of the extracts were cytotoxic to the THP-1 monocytic leukemia cells and HDFn normal human dermal fibroblasts. For both HCT-116 and HT-29, these extracts significantly up-regulated (P<0.05) the expression of c-fos and c-jun compared to the untreated negative control. Conclusions: The results of this study suggest that cytotoxicity of stem MeOH, stem EtOH, and berry EtOH extracts of S. dulcificum on HCT-116 and HT-29 colon cancer cells is due to the induced apoptosis which is caused by the up-regulation of the expression of early apoptotic genes, c-fos and c-jun
Deberes formales del contribuyente y el RUC según el código tributario y la ley de registro único de contribuyentes
No full textSRTrabajo de investigació
Recensiones [Revista de Historia Económica Año V Otoño 1987 n. 3 pp. 601-647]
Get PDFFrançoise Dosse. L'histoire en miettes. Des «Annales» a la «nouvelle histoire» (Por Femando G. Jaén).--
Jerónimo López-Salazar Pérez. Estructuras agrarias y sociedad rural en La Mancha (siglos XVI-XVII) (Por Enrique Llopis).--
Agustín Guimera Ravina. Burguesía extranjera y comercio atlántico: la empresa comercial irlandesa en Canarias (1703-1771) (Por Pedro Pérez Herrero).--
JMiguel Molina Martínez.El Real Tribunal de Minería de Lima (1785-1821) (Por Kenneth J. Andrien).--
Bárbara A. Tenenbaum. México en la época de los agiotistas, 1821-1857 (Por Inmaculada Romero-Hombrebucno).--
Joan Boadas i Raset. Girona després de la Guerra de Successió. Riquesa urbana i estructura social al primer quart del segle XVIII (Por Enriqueta Camps).--
V. Pinilla Navarro. Teruel (1833-1868). Revolución burguesa y atraso económico (Por M. Teresa Pérez Picazo).--
Jordi Nadal y otros. Catalunya, la fabrica d'Espanya (Un siglo de industrialización catalana, 1833-1936) (Por Sebastián Coll Martín).--
J. SardáDexeus. Escritos (1948-1980) (Por Pablo Martín Aceña).--
Esperanza Frax. Puertos y comercio de cabotaje en España, 1857-1934 y El mercado interior y los principales puertos, 1857-1920 (Por A. Gómez Mendoza).--
Vicent Soler Marco. Guerra i expansió industrial: Pais Valencia (1914-1923) (Por Albert Carreras).--
Guillermo Cortázar. Alfonso XIII, hombrede negocios. Persistencia del Antiguo Régimen, modernización económica y crisis política, 1902-1931 (Por Gabriel Tortella).--
S. N. Broadberry The British Economy between the Wars. A Macroeconomic Survey (Por Francisco Comín)Publicad
. 25 Año 8 (2011) enero-abril. Señales de humo
No full text- Editorial por Hugo Reynoso Urtiz. - Donde los humanos cazaron elefantes hace 12, 000 años. El fin del mundo por Guadalupe Sánchez Miranda. - Un paso más en la protección del patrimonio cultural por Esperanza Donjuan Espinoza. - Rescate de Nuestra Señora de la Purísima Concepción Purísima Concepción de María del templo de San José de Guaymas por Rodolfo del Castillo López. - La Pintada inédita por Eréndira Contreras Barragán. - Cerro de Trincheras: Evidencia gráfico-rupestre por Carlos Cruz Guzmán. - Elisa Villapando Canchola por Julio C. Montané y Denisse Cejudo Ramos. - Escultura retorna a su Santa Casa Virgen de Loreto por Esperanza Donjuan Espinoza. - Saldos de la Revolución por Juan José Gracida Romo. - Las manifestaciones gráfico rupestee de Tepache, Sonora por César A. Quijada López y Tomás Pérez Reyes
ABC genotyping and putative virulence factors of Candida albicans clinical isolates
No full textAims: Candida albicans is a diploid yeast which interacts with the host in a complex nature involving several fungal virulence factors and host\u27s response. In this study, we investigated the different ABC genotypes of 26 clinical C. albicans isolates which is based on the presence of absence of transposable intron in the 25S rDNA, and the phenotypic expression of their virulence factors: phospholipase production, esterase production, haemolytic activities, biofilm formation, and white-opaque switching. Methodology and results: In this study, we investigated the ABC genotypes of 26 clinical C. albicans isolates, and the phenotypic expression of their virulence factors. The C. albicans isolates were tested for their in vitro abilities in exhibiting the following virulence factors: phospholipase, biofilm, esterase, hemolysin and phenotypic switching. Phospholipase activities and biofilm formation were detected in 57.7% and 65.38% of the isolates, respectively. All of the isolates showed phenotypic white-type colony, while none showed esterase and hemolytic activities. ABC genotyping revealed that 50% of the isolates were grouped under Genotype A, followed by Genotype C (42.3%), and B (7.69%). Conclusion, significance and impact of study: This study provides information in regard to virulence potential and the ABC genotype of C. albicans from the Philippines. © 2019, Universiti Sains Malaysia
TANGOS / XAVIER MARTELL y su orquesta
No full textComprend : UN CLAIR DE LUNE A MAUBEUGE / P. PERRIN, C. BLONDY - ROSA / JACQUES BREL - LES BRAS D'ANTOINE / GUY BEART - LA JOCONDE / MICK MICHEYL - JE NE SAIS JAMAIS DIRE NON / GUY BEART - ESPERANZA / R. CABRERA, CH. AZNAVOUR - QUAND UN HOMME / G. BEART, M. AYME - L'HORRIBEL TANGO / CHARLES TRENET - SI TU M'ECRIVAIS / A. VERCHUREN, F. BAXTER - PLUS JAMAIS / G. BEART, L. DE VILMORINBnF-Partenariats, Collection sonore - BelieveContient une table des matière
Detection of azole resistance and ERG11 point mutations in Candida albicans isolates from tertiary hospitals in the Philippines
No full textCandida albicans is commonly isolated from nosocomial fungal infections, and controlling these infections depends on the immune status of the patient, gravity of the infection, and the choice of the administered antifungal drug. Increasing worldwide reports of strains that are resistant to the azole drugs, which are commonly used for treatment of diseases caused by C. albicans, warrant the conduct of drug susceptibility testing of clinical isolates, which is not routinely done in the Philippines. Twenty-six local C. albicans clinical isolates were tested for their susceptibility to the azole drugs fluconazole and voriconazole using the standard disc agar diffusion method. Likewise, the ERG11 gene coding for lanosterol-14-α-demethylase involved in ergosterol synthesis, which is the target of the azole drugs, was studied for the occurrence of point mutations. Results of the assay showed phenotypic resistance patterns to both drugs in 19 isolates (or 73.08%). Six isolates were determined susceptible to both drugs, while one isolate was susceptible-dose dependent also to both antifungals. Detection of ERG11 mutations following nucleotide sequencing revealed the presence of point mutations A369C, T462C and C558T. Mutations A369C and T462C have been identified as possible factors associated with the resistance to azole agents in previous studies. The results imply that it is imperative to continuously perform susceptibility testing on clinical isolates of C. albicans for effective treatment management and for the surveillance of antifungal resistance in the organism
Contribución al conocimiento de la biología y taxonomía de un hongo del género Phytium aislado del "aliso", Alnus acuminata HBK
Get PDFSome biological aspects of an isolated fungus of Alnus acuminata roots were studied. It bas been found Tbat between OOC and 4°C tbe fungi grows fast. This condition can result in a important factor in the ecophysiology of 'Aliso' populations, that grows in secondary forests at sub-paramo, After a review of the taxonomic literature, we placed it in the Phytium genus, but not in a particular described species. We assume that it is a new species. We modificated the microculture technique that was simpler and safer and them we made direct observations about tbe fungus growtb and development. As for now it is nominated as Phytiun near Mammillatum Meurs. Palabras Claves: Phytium, bongos, A/nus acuminata HBK., "Aliso"
Methicillin resistant staphylococcus aureus (MRSA)
No full textStaphylococcus aureus has been recognized as an extremely successful hospital pathogen that has established itself firmly in the community as well. In addition to its compendium of virulence factors, it has the immense propensity to develop resistance to antimicrobials belonging to different classes. The emergence of methicillin resistant S. aureus (MRSA) that carries transferable multiple antibiotic resistance to the class of β-lactams alone or to other antimicrobials as well, is a serious public health concern. The development of community-associated MRSA (CA-MRSA) from a genetic lineage different from that of hospital-associated MRSA (HA-MRSA) was unexpected, as was the observation that different strains of CA-MRSA from different parts of the world co-evolved simultaneously. Considering these observations with the virulence of the organism, and the transferable nature of the methicillin resistance genetic element, it is not surprising that MRSA is regarded as a pathogen that warrants utmost attention of the medical and scientific community. The need for urgent measures for its control cannot be overemphasized. © 2012 Bentham Science Publishers. All rights reserved
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