1,720,972 research outputs found
The Southampton Breast Cancer Data System: A Transformational Cancer Informatics System in the University Hospital of Southampton/University of Southampton Clinical Data Environment
No full textIntroductory notes for South Central Research Design Service on behalf of the UHS and UoS Bioinformatics Initiativ
Creation of a comprehensive, unitary, episode-structured, visually rich data system of 12,000+ breast cancer patients with 30 year follow up for MDT decision assistance
No full textIntroduction: Clinical and MDT decision making for patients with breast cancer and other chronic diseases is handicapped by the lack of reliable long term follow up; of robust measures of final outcome, including accurate death certification; and of tools for the ready visualisation and radical simplification of complex data sets.Method: We have used a comprehensive manual card index of 12,000+ patients, treated within this Centre since 1980, to populate a novel episode based data system, (the e-Breast Card Index, e-BCI). We have assessed and recorded the “true” cause of death (COD), crosschecking a 100Gb Trust repository of contemporary e-documents, built up since 1996, against national death notifications. Innovative interactive data visualisation tools present the speciality-structured life histories of each and every patient on a single screen (the “Life-Lattice”) and the linear episodic history of each patient from diagnosis to final outcome on a single “Cancer Life-Track”. Patient accrual and analysis is continuous and progressively automated.Results: In six months during 2012, 30 years of handwritten and legacy records have been collated into a unitary digital data system with evolving functionality and graphically rich, locally developed “lifeline” visualisation tools for individual patient records and cohort analysis. Timeline structuring of primary presentations, recurrences and the appearance of metastases provides immediate visualisation of clinical outcomes in relation to treatments. 5,800 of the 12,000 patients have died of all causes, which are recorded in detail.Conclusions: The Southampton e-BCI creates a benchmark for novel, intuitive, clinician and MDT focussed decision assist tools. It uses temporally structured data from a range of sources to seek out the “ground truths” in the relationship between therapeutic inputs and definitive outcomes in a large, longitudinal, heterogeneous, and well validated cohort of breast cancer patients
EP.FRI.745 Information Sustainability: SCR+: A bespoke module to optimise information flows around the Somerset Cancer Register to enhance the multidisciplinary cancer team process
No full textBackground: many surgeons work within multidisciplinary cancer teams. The Somerset Cancer Register (SCR) is a national reporting system for service performance which is in use in more than 100 NHS Trusts. However, the core system has not yet been optimised for MDT users or for the surfacing of clinical data for research and other uses.Methods: SCR replaced our legacy cancer reporting system in 2014. Working with the SCR developers, we integrated our cellular pathology and imaging records with the SCR MDT outputs. We subsequently developed SCR+ to optimise workflows for MDT coordinators and information presentation to clinical users. Results: our HTML-enabled SCR+ software application displays all cancer patients by pathological type and year of presentation on dynamic histograms, for ease of visualisation and interaction. Every selected case is displayed in list order for each and every MDT meeting, with a fast hyperlink to our integral Lifelines EPR interface, to electronic pathology records back to 1990, and to our Breast Cancer Data System for relevant patients.Conclusions: the SCR+ module transforms the access and visualisation of cancer workload across our Trust for all authorised MDT users, with appropriate data security. The agile programming methodology allowed us to build a sustainable cancer data system with further development potential. The product substantially enhances user experience, data recall and productivity over legacy systems. Close cooperation between clinically proficient IT teams and clinicians as the end consumers of digital health data systems yields significant operational benefits at pace and with very modest costs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
SP8.1.4 Design features of the EPR-integrated Southampton Breast Cancer Data System (SBCDS), with timeline structured whole-of-life records on 20,000 sequential cases since the 1970s
No full textIntroduction: the digitisation of the electronic patient record (EPR) provides transformative opportunities for data visualisation. The synchronised timeline and iconographic interface permits the whole-of-life display, navigation and interpretation of all documents and reports of each and every EPR on a single screen, thus substantially facilitating clinical research.
Methods: since 2010, we have conceived, programmed and iterated a radical interface, UHS Lifelines, within our Trust EPR using agile methodology. It is live for >2.5M record sets, and enriched with cellular pathology records back to 1990. We have integrated this interface into a unique, HTML-enabled, dynamic and continually updated database for the recording of treatments and pathologies of all cases of breast neoplasia from our current and historic record sets.
Results: as of January 2021, our data system contains ∼20,000 sequential whole of life records of patients with breast neoplasia, including ∼15,000 locally diagnosed and ∼ 5,000 externally referred cases. The unique Cancer Lifetrack timelines displays the disease course of every case from primary diagnosis, through loco-regional recurrence, to distant metastasis, other morbid cancers and cause of death, where relevant. An integral data mining system permits a wide range of analyses.
Conclusions: we believe our Breast Cancer Data System to be the first-in-class exemplar of a new and proven approach to clinical data visualisation. It permits near-instantaneous oversight and real time updating of every patient record in the system. We recognise its potential application for the whole-of-life study of all chronic diseases of childhood and adulthood as the model is more widely adopted
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
