103,684 research outputs found
The quest for precision oncology with immune checkpoint inhibitors for hepatocellular carcinoma
No full textN
Antiviral therapy in the palliative setting of HCC (BCLC-B and -C)
No full textThe potential impact of direct-acting antivirals (DAAs) in patients with Barcelona Clinic Liver Cancer (BCLC)-B/C stage hepatocellular carcinoma (HCC) is understudied. Patients with HCC have been systematically excluded from randomised controlled trials evaluating the effectiveness of DAAs. Thus, the benefits of DAAs in patients with HCC are less well defined. The presence of active HCC before the initiation of DAA treatment is reported to be a predictor of DAA failure, and studies in patients without HCC have demonstrated that improvements in cirrhosis complications were lower or absent after DAA failure. Even if viral eradication is achieved using DAAs, reversal of liver function impairment may take longer than the development of end-stage cancer status. Additionally, the impact of DAAs on HCC recurrence is still a controversial topic. Thus, the decision of whether to use DAAs should be made on a patient-by-patient basis, and each patient should be informed of all the potential risks and benefits associated with their usage. This document summarises the current data on the usage of DAAs in BCLC-B/C patients, discusses the concept of “the point of no return” in the setting of DAAs, and proposes tools for deciding the best option for each patient profile. If liver function improvement overlaps with symptomatic HCC progression, the benefits of DAAs could be minimised, worsened, or fully counterbalanced. If the BCLC stage is defined using only liver dysfunction, the decision to prioritise DAA treatment should be based on the option (or lack thereof) of liver transplantation and/or the HCC stage. We propose applying a shared decision-making approach, informing each patient of all the potential risks and benefits of the proposed medical intervention
Database Cooperation: Classification and Middleware Tools
No full textWe propose new criteria for the classification of systems for database cooperation, based on the nature of the component databases. In fact, the traditional criteria --- heterogeneity, distribution, and autonomy --- are often constraints for the design process, rather than design parameters. In this case, other features of the component databases should be addressed. We claim that a more useful classification can be based on three new criteria: (a) degree of transparency, (b) complexity of operations, and (c) level of liveliness of data. This leads us to distinguish three main categories of systems: (i) multidatabases, (ii) data warehouses, (iii) local information systems with external data. For each of these categories we discuss implementations based on tools offered by currently available technology
ISALOG- : A Deductive Language with Negation for Complex-Object Databases with Hierarchies
No full textThe IsaLog ¬ model and language are presented. The model has complex objects with classes, relations, and isa hierarchies. The language is strongly typed and declarative. The main issue is the definition of the semantics of the IsaLog language. The novel features are mostly due to the interaction of hierarchies with negation in the body of rules. Two semantics are presented and shown to be equivalent: a stratified semantics based on an original notion of stratification, needed in order to correctly deal with hierarchies, and a reduction to logic programming with function symbols. The solutions are based on a new technique (explicit Skolem functors) that provides a powerful tool for manipulating object identifiers
Cabibbo Tommaso
No full textRicostruzione storica dell'attività libraria ed editoriale di Cabibbo Tommaso con riguardo alla produzione di libri educativi e scolastici e dei corrispettivi modelli educativi e didattici
Il miracolo nel Mezzogiorno d'Italia dell'età moderna tra santi, madonne, guaritrici e medici (G. Sodano)
No full textA measurement of the Cabibbo-suppressed decays D0 → pi−pi+ and D0 → K−K+
No full textWe report a measurement of the relative branching ratio of two Cabibbo-suppressed decay modes: D0 → pi−pi+ and D0 → K−K+. The data were accumulated in the 1990–1991 fixed target run of Fermilab high energy photoproduction experiment E687. The branching ratios of these modes relative to the Cabibbo-allowed decay D0 → K−pi+ are also presented. The relative branching ratios are measured to be G(D0 → KK)/G(D0 → pi pi) = 2.53 +- 0.46 +- 0.19, G(D0 → KK)/G(D0 → Kpi) = 0.109 +- 0.007 +- 0.009, and Γ(D0 → pi pi)/Γ(D0 → K pi) = 0.043 +- 0.007 +- 0.003
Il "meraviglioso fisiologico" di veronica Giuliani fra modello francescano ed erudizione barocca
No full textPion-pion scattering and the decay amplitudes
No full textWe revisit the recently proposed method for the determination of the pi-pi scattering length combination a_{0}-a_{2}, based on the study of the pi0 pi0 spectrum in K+ -> pi+ pi0 pi0. In view of a precision measurement, we discuss here the effects due to smaller absorptive contributions to the K+ -> pi+ pi0 pi0 and K+ -> pi+ pi+ pi- amplitudes. We outline a method of analysis that can lead to a precision determination of a_{0}-a_{2} and is based on very general properties of the S matrix. The discussion of final-state rescattering and cusp effects is also extended to the two K_L -> 3pi coupled channels. Thanks to the present work, the theoretical error on the a_{0}-a_{2} combination extracted from the K+ -> pi+ pi0 pi0 spectrum is reduced to about 5%. A further reduction requires the evaluation of the effects arising from radiative corrections.We revisit the recently proposed method for the determination of the pi-pi scattering length combination a_{0}-a_{2}, based on the study of the pi0 pi0 spectrum in K+ -> pi+ pi0 pi0. In view of a precision measurement, we discuss here the effects due to smaller absorptive contributions to the K+ -> pi+ pi0 pi0 and K+ -> pi+ pi+ pi- amplitudes. We outline a method of analysis that can lead to a precision determination of a_{0}-a_{2} and is based on very general properties of the S matrix. The discussion of final-state rescattering and cusp effects is also extended to the two K_L -> 3pi coupled channels. Thanks to the present work, the theoretical error on the a_{0}-a_{2} combination extracted from the K+ -> pi+ pi0 pi0 spectrum is reduced to about 5%. A further reduction requires the evaluation of the effects arising from radiative corrections
- …
