1,720,966 research outputs found
Effect of oxidative stress on canonical/non-canonical WNT pathways in colon cancer cell lines
No full textThe importance of aberrant regulation of Wnt/β-Catenin signaling in the pathogenesis and colorectal cancer progression has long been recognised. Recent studies have shown that reactive oxygen species (ROS) production activates the Wnt/β-Catenin pathways, but the mechanisms involved remain unclear. Excess in ROS production is linked to chronic inflammation and promotes DNA damages and repair systems.
We aim to evaluate the relationship among oxidative stress response and canonical/non-canonical Wnt pathways in colorectal cancer cell line models with different Wnt signaling behaviour
Thyroid carcinoma usually occurs in patients with familial adenomatous polyposis in the absence of biallelic inactivation of the adenomatous polyposis coli gene
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Analysis of extended genomic rearrangements in oncological research.
Full text linkScreening for genomic rearrangements is a fundamental task in the genetic diagnosis of many inherited
disorders including cancer-predisposing syndromes. Several methods were developed for analysis of structural
genomic abnormalities, some are targeted to the analysis of one or few specific loci, others are designed to
scan the whole genome. Locus-specific methods are used when the candidate loci responsible for the specific
pathological condition are known. Whole-genome methods are used to discover loci bearing structural
abnormalities when the disease-associated locus is unknown. Three main approaches have been employed for
the analysis of locus-specific structural changes. The first two are based on probe hybridization and include
cytogenetics and DNA blotting. The third approach is based on PCR amplification and includes microsatellite or
single nucleotide polymorphism (SNP) genotyping, relative allele quantitation, real-time quantitative PCR, long
PCR and multiplex PCR-based methods such as multiplex ligation-dependent probe amplification and the
recently developed nonfluorescent multiplex PCR coupled to high-performance liquid chromatography analysis.
Whole-genome methods include cytogenetic methods, array-comparative genomic hybridization, SNP array
and other sequence-based methods. The goal of the present review is to provide an overview of the main
features and advantages and limitations of methods for the screening of structural genomic abnormalities
relevant to oncological research
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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