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Comparison of different concentration of ropivacaine in spinal anesthesia for vascular surgery
No full textBackground and Goal of Study: Plain ropivacaine 0,5% vial has been recentely introduced and recommended for intrathecal use. The aim of this randomized study was to compare clinical efficacy and safety of 15 mg plain ropivacaine in different concentration given intrathecally in patients scheduled for vascular surgery (saphenectomies, femoro‐popliteal by‐pass and peripheral aneurysms).Materials and Methods: 38 ASA III patients (mean age 65.5±8.0 years) were scheduled after obtaining written informed consent. All patients had a history of arterial hypertension and other cardiovascular disorders pharmacologically treated. They were divided into two groups A(19 patients) and B (19 patients) receiving respectively ropivacaine 0,75 % 15 mg in a bolus of 2 ml and ropivacaine 0,5 % 15 mg in a bolus of 3 ml. Profile of spinal block (onset and recovery times) and quality of anesthesia (Bromage 0–3 score and pinprick test) were recorded (1). Pulse rate (HR), mean arterial pressure (MAP), cardiac output (CO), left ventricular contractility (dP/dt), systemic vascular resistance (SVR) and global end‐diastolic volume (GEDV) were monitored by the PiCCO System Pulsion in order to evaluate their variations (2). ANOVA test was applied for statistical analysis.Results and Discussion: The median times to onset of complete regression of sensory (140 vs 240 sec; p<0.001) and motor block (175 vs 320 sec; p<0.001) were longer in group B. The quality of sensory and motor block was superior in the group A. The prinpick test at S2 level was similar in both groups. The Bromage scale showed a profile of 2–3 score in group A compared to 1–2 score in group B. 5 patients of group B received additional anesthesia with continuous infusion of propofol 3mg/kg/h because of the poor efficacy of the spinal block. Cardiovascular parameters were not influenced in both groups.Conclusion(s): Spinal anesthesia produced with 15 mg plain ropivacaine 0,75% in a volume of 2 ml is effective and safe in ASA III patients. The concentration of 0,75% gives a complete spinal block in high risk patients without side effects and cardiovascular modifications. A concentration of 0,5% fails to determine an adequate anesthesia level required for vascular surgery and did not offer any advantage in terms of comfort, safety and rapid recovery.
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References:
1 Camorcia M, Capogna G, Lyons G et al. Anesth and Analg 2004; 98: 1779-84.
Cited Here...
2 Buhre W, Weyland A, Kazmaier S et al. J Cardiothorac Vasc Anesth 1999; 13: 437-440.
Cited Here... | PubMed | CrossRe
Comparison of different concentration of ropivacaine in spinal anesthesia for vascular surgery
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Going Beyond Counting First Authors in Author Co-citation Analysis
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Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
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koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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