36 research outputs found
The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants
No full text博士論文 要旨Abstract/本文Full 以下に掲載：Journal of Molecular and Cellular Cardiology 177 pp.50-61 2023. Elsevier. 共著者：Shihe Cui, Kenshi Hayashi, Isao Kobayashi, Kazuyoshi, Hosomichi, Akihiro Nomura, Ryota Teramoto, Keisuke Usuda, Hirofumi Okada, Yaowen Deng, Jingjing Kobayashi-Sun, Tetsuo, Nishikawa, Hiroshi Furusho, Takekatsu Saito, Hiroaki Hirase, Kunio Ohta, Manabu Fujimoto, Yuki Horita, Takashi Kusayama,Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Soichiro Usui, Kenji Sakata, Noboru Fujino, Atsushi Tajima, Masakazu, Yamagishi, Masayuki Takamur
The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants
No full text金沢大学博士(医学）博士論文 要旨Abstract/本文Full 以下に掲載：Journal of Molecular and Cellular Cardiology 177 pp.50-61 2023. Elsevier. 共著者：Shihe Cui, Kenshi Hayashi, Isao Kobayashi, Kazuyoshi, Hosomichi, Akihiro Nomura, Ryota Teramoto, Keisuke Usuda, Hirofumi Okada, Yaowen Deng, Jingjing Kobayashi-Sun, Tetsuo, Nishikawa, Hiroshi Furusho, Takekatsu Saito, Hiroaki Hirase, Kunio Ohta, Manabu Fujimoto, Yuki Horita, Takashi Kusayama,Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Soichiro Usui, Kenji Sakata, Noboru Fujino, Atsushi Tajima, Masakazu, Yamagishi, Masayuki Takamuradoctoral thesi
発熱起因性のQT延長およびトルサードドポアントが生じるメカニズム
No full text博士論文 要旨Abstract/本文Full 以下に掲載：EP Europace 25(6) euad 161- 2023. Oxford Academic. 共著者：Keisuke Usuda, Kenshi Hayashi, Tadashi Nakajima, Yasutaka Kurata, Shihe Cui, Takashi Kusayama, Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Kenji Sakata, Soichiro Usui, Noboru Fujino, Yoshihiro Tanaka, Yoshiaki Kaneko, Masahiko Kurabayashi, Shoichi Tange, Takekatsu Saito, Kunio Ohta, Masakazu Yamagishi, Masayuki Takamur
発熱起因性のQT延長およびトルサードドポアントが生じるメカニズム
No full text金沢大学博士(医学）博士論文 要旨Abstract/本文Full 以下に掲載：EP Europace 25(6) euad 161- 2023. Oxford Academic. 共著者：Keisuke Usuda, Kenshi Hayashi, Tadashi Nakajima, Yasutaka Kurata, Shihe Cui, Takashi Kusayama, Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Kenji Sakata, Soichiro Usui, Noboru Fujino, Yoshihiro Tanaka, Yoshiaki Kaneko, Masahiko Kurabayashi, Shoichi Tange, Takekatsu Saito, Kunio Ohta, Masakazu Yamagishi, Masayuki Takamuradoctoral thesi
Emerg Infect Dis
No full textWe studied 47 hepatitis E virus (HEV) isolates from hospitalized patients in Nanjing and Taizhou, eastern China. Genotypes 1, 3, and 4 were prevalent; genotype 3 and subgenotype 4b showed a close relationship with the swine strains in eastern China, thus indicating that HEV genotype 3 had infected humans in China
Two-dimensional structure Au nanosheets are super active for the catalytic reduction of 4-nitrophenol
No full textTwo-dimensional structure Au nanosheets with a polygon morphology and controlled thicknesses of ∼15 nm, ∼35 nm, and ∼50 nm were successfully synthesized by a one-step solution reduction method. Scanning and transmission electron microscopy (SEM and TEM), selected area electron diffraction (SEAD) analyses, and X-ray diffraction (XRD) were used to thoroughly study the structure and the formation mechanism of the nanosheets. The catalytic activity of the Au nanosheets was investigated for the reduction of 4-nitrophenol (4-NP) by UV-visible absorption spectroscopy. Against all expectation, the Au nanosheets with such a big lateral (more than 1 μm) size exhibited superior catalytic activity on the selective reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) in the presence of NaBH4. On the other hand, the catalytic activity does closely depend on the thickness of the nanosheets; that is, it decreases with increasing thickness. The reaction can be completed in less than 1 min when catalyzed by Au nanosheets about 15 nm thick. The 100% conversion efficiency was further demonstrated after two catalytic cycles with the thinnest Au nanosheets.</p
Synthesis of Li-doped Co<sub>3</sub>O<sub>4</sub> truncated octahedra with improved performances in CO oxidation and lithium ion batteries
No full textSingle-crystalline Li-doped Co3O4 truncated octahedra with different doping contents were synthesized by a simple combustion method with the fuel of multi-walled carbon nanotubes (MWCNTs). Controlled experiments showed that the pristine well-defined Co3O4 octahedra were obtained with exposed surfaces of {111} planes without lithium doping. In comparison with the octahedra, the truncated Co3O4 octahedra were composed of original {111} planes and extra {100} planes. It could be attributable to the selective adsorption of lithium ions on the {100} planes, making these planes with higher surface energy coexist with the crystal faces of {111}. Furthermore, the Li-doped truncated octahedra and undoped octahedra were used as catalysts in CO oxidation and as anode materials for Li-ion batteries (LIBs). The measurements exhibited that the Li-doped octahedra with added {100} crystal faces showed improved catalytic activity and electrochemical property because of the exposure of the higher energy faces of {100} and enhanced conductivity by Li doping.</p
Research on the flow characteristics of opening unit in the rotor spinning unit
No full textThe opening unit is an important device in a rotor spinning unit to comb fibres and remove trash. In this paper, numerical simulation is carried out to study the flow structure in the rotor spinning channel and the trash removal process in the trash removal unit. Firstly the effect of the opening unit on the airflow field in the rotor channel is investigated by singlephase simulation. The result shows that the effective area for fibre conveyance enlarges as the absolute value of negative pressure at the outlet increases, while it decreases as the opening roller speed increases. However, the effect of the negative pressure and the opening roller speed on the length of the vortex in the axial direction is quite small. Secondly the trash separation process in the trash removal unit is simulated using the Discrete Phase Model (DPM). Suitable rotational speeds of particles of different diameters are acquired. These results could provide a valuable reference for parameter selection in the trash-removal process.</jats:p
Communication molecules (ncRNAs) mediate tumor-associated macrophage polarization and tumor progression
No full textNon-coding RNAs play important roles in tumor cells and macrophages and participate in their communication as messengers. Non-coding RNAs have an impact in tumor cell proliferation, migration, and apoptosis, and they also regulate the differentiation and regulation of immune cells. In macrophages, they stimulate the polarization of macrophages into M1 or M2 by regulating proteins related to signaling pathways; in tumor cells, non-coding RNAs can enter macrophages through exosomes and affect the latter polarization. The polarization of macrophages further regulates the biological functions of cancer cells. The direction of macrophage polarization determines tumor progression, angiogenesis and drug resistance. This often creates a feedback loop. Non-coding RNAs act as bridges between tumor cells and macrophages to regulate the balance of the tumor microenvironment. We reviewed the signaling pathways related to macrophage polarization and the regulatory mechanisms of non-coding RNA in tumor-associated macrophages M1 and M2, and discussed the potential applications and prospects of exosome engineering
The application of Deviation Minimization Model to determine the cost price in the tendering of highway engineering
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