221 research outputs found
An unusual case of transient neonatal pustular melanosis: a diagnostic puzzle.
No full textA newborn's skin may exhibit a variety of changes during the first weeks of life, and rashes are extremely common in the neonatal period, representing a significant source of parental concern. In particular, a variety of skin eruptions can present as pustules. Most of them are innocuous and self-limiting, while others can be the manifestation of an infectious disease or even indicative of serious underlying disorders. Transient neonatal pustular melanosis is an uncommon vesiculopustular rash characterized by small pustules on a non-erythematous base, noted at birth or during the first day of life, without systemic symptoms. The lesions rupture spontaneously, leaving hyperpigmented macules that usually fade within few weeks. Clinical recognition of this disease can help physicians avoid unnecessary diagnostic testing and treatment for infectious etiologies because no specific therapy is recommended. The clinical aspect and time of onset are generally sufficient to make the correct diagnosis. Nevertheless, peculiar clinical presentations may require additional work-up to rule out life-threatening conditions, and dermatological consultation and histological examination are required for the final diagnosis. Conclusion: We report an exceedingly unusual presentation of transient neonatal pustular melanosis, suggesting the importance of a systematic diagnostic approach to allow a confident recognition of this benign condition
Primary cutaneous epidermotropic, cytotoxic, ALK+ T-cell lymphoma: observation of a novel case and review of the literature point at a discrete pattern of disease, with response to target therapy
No full textEruptive Pseudoangiomatosis: Clinicopathological Report of 20 Adult Cases and a Possible Novel Association with Parvovirus B19
No full textLong-term remission of erythrodermic mycosis fungoides after persistent control of hepatitis B infection
No full text3D bioprinting of multi-layered segments of a vessel-like structure with ECM and novel derived bioink
No full text3D-Bioprinting leads to the realization of tridimensional customized constructs to reproduce the biological structural complexity. The new technological challenge focuses on obtaining a 3D structure with several distinct layers to replicate the hierarchical organization of natural tissues. This work aims to reproduce large blood vessel substitutes compliant with the original tissue, combining the advantages of the 3D bioprinting, decellularization, and accounting for the presence of different cells. The decellularization process was performed on porcine aortas. Various decellularization protocols were tested and evaluated through DNA extraction, quantification, and amplification by PCR to define the adequate one. The decellularized extracellular matrix (dECM), lyophilized and solubilized, was combined with gelatin, alginate, and cells to obtain a novel bioink. Several solutions were tested, tuning the percentage of the components to obtain the adequate structural properties. The geometrical model of the large blood vessel constructs was designed with SolidWorks, and the construct slicing was done using the HeartWare software, which allowed generating the G-Code. The final constructs were 3D bioprinted with the Inkredible + using dual print heads. The composition of the bioink was tuned so that it could withstand the printing of a segment of a tubular construct up to 10 mm and reproduce the multicellular complexity. Among the several compositions tested, the suspension resulting from 8% w/v gelatin, 7% w/v alginate, and 3% w/v dECM, and cells successfully produced the designed structures. With this bioink, it was possible to print structures made up of 20 layers. The dimensions of the printed structures were consistent with the designed ones. We were able to avoid the double bioink overlap in the thickness, despite the increase in the number of layers during the printing process. The optimization of the parameters allowed the production of structures with a height of 20 layers corresponding to 9 mm. Theoretical and real structures were very close. The differences were 14% in height, 20% internal diameter, and 9% thickness. By tailoring the printing parameters and the amount of dECM, adequate mechanical properties could be met. In this study, we developed an innovative printable bioink able to finely reproduce the native complex structure of the large blood vessel
The General Pathology
No full textThe definition of indolent lymphoma implies a lymphoid proliferation characterized, in the majority of the clinical scenarios, by a protracted, chronic course of disease, manageable over time, albeit not definitely curable. From the standpoint of the pathologist in charge of the diagnostic tissue workup, indolent grossly overlaps with so-called low grade, that is, composed of cells resembling the mature, non-blastic counterparts of the immune system, which are lymphocytes, centrocytes, plasma cells, and variants of these. This definition is formally not part of the WHO classification but still influences the diagnostic practice. A notable exception to the rule that links non-blastic morphology with indolent clinical behavior is mantle cell lymphoma, a proliferation of (mostly) small centrocytes, which presents an aggressive clinical behavior in a subset of patients. All these need to be kept in mind by both the hematologist and the pathologist when using the the “indolent” lymphoma
Poesia e prosa porosas: um manifesto de Alberto Pucheu em favor da criação
No full texton the poetic and critical making, seen as a creating attitude. For the author, there is a fusion between poetry and criticism which are areas of knowledge that are in a process of “dissolving boundaries”, whose encounter takes place within the creation itself. In this hybrid approach, we will seek to understand the way in which the fusion between these fields occurs, focusing on the poststructuralist thought, based on Roland Barthes, Gilles Deleuze and Giorgio Agamben. O presente trabalho faz uma leitura da obra de Alberto Pucheu, trazendo à luz a discussão sobre o fazer poético e crítico, vistos como uma atitude primordialmente criadora. Para o autor, existe uma indistinção entre poesia e crítica, que são saberes que se encontram em um “desguarnecimento de fronteiras”, cujo encontro se dá no interior da própria criação. Nessa perspectiva híbrida, buscar-se-á compreender a maneira pela qual ocorre a fusão entre esses campos, privilegiando o pensamento de pós-estruturalistas, como Roland Barthes, Gilles Deleuze e Giorgio Agamben.En este artículo se presenta una lectura de la obra de Alberto Pucheu, estableciendo una discusión sobre el quehacer poético y crítico, observados como una actitud primordialmente creativa. Para el autor hay una fusión entre poesía y crítica, que son saberes que están “desguarnecidos de fronteras”, cuyo encuentro acontece en el interior de la propia creación. A partir de esa perspectiva híbrida, se busca comprender de qué forma acontece la fusión de esos campos, privilegiando el pensamiento de post-estructuralistas como Roland Barthes, Gilles Deleuze y Giorgio Agamben
Poesia e prosa porosas: um manifesto de Alberto Pucheu em favor da criação
No full texton the poetic and critical making, seen as a creating attitude. For the author, there is a fusion between poetry and criticism which are areas of knowledge that are in a process of “dissolving boundaries”, whose encounter takes place within the creation itself. In this hybrid approach, we will seek to understand the way in which the fusion between these fields occurs, focusing on the poststructuralist thought, based on Roland Barthes, Gilles Deleuze and Giorgio Agamben. En este artículo se presenta una lectura de la obra de Alberto Pucheu, estableciendo una discusión sobre el quehacer poético y crítico, observados como una actitud primordialmente creativa. Para el autor hay una fusión entre poesía y crítica, que son saberes que están “desguarnecidos de fronteras”, cuyo encuentro acontece en el interior de la propia creación. A partir de esa perspectiva híbrida, se busca comprender de qué forma acontece la fusión de esos campos, privilegiando el pensamiento de post-estructuralistas como Roland Barthes, Gilles Deleuze y Giorgio Agamben.O presente trabalho faz uma leitura da obra de Alberto Pucheu, trazendo à luz a discussão sobre o fazer poético e crítico, vistos como uma atitude primordialmente criadora. Para o autor, existe uma indistinção entre poesia e crítica, que são saberes que se encontram em um “desguarnecimento de fronteiras”, cujo encontro se dá no interior da própria criação. Nessa perspectiva híbrida, buscar-se-á compreender a maneira pela qual ocorre a fusão entre esses campos, privilegiando o pensamento de pós-estruturalistas, como Roland Barthes, Gilles Deleuze e Giorgio Agamben
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