6,145 research outputs found
Computing the Cramer-Rao bound of Markov random field parameters: Application to the Ising and the Potts models
No full textThis letter considers the problem of computing the Cramer–Rao bound for the parameters of a Markov random field. Computation of the exact bound is not feasible for most fields of interest because their likelihoods are intractable and have intractable derivatives. We show here how it is possible to formulate the computation of the bound as a statistical inference problem that can be solve approximately, but with arbitrarily high accuracy, by using a Monte Carlo method. The proposed methodology is successfully applied on the Ising and the Potts models
SC author and illustrator Kate Salley Palmer signing book
No full textPhotograph of SC author and illustrator Kate Salley Palmer signing boo
Book signing by SC author and illustrator Kate Salley Palmer
No full textPhotograph of Book signing by SC author and illustrator Kate Salley Palme
Correlation between genetic polymorphisms and stroke recovery: analysis of the GAIN Americas and GAIN International Studies
No full textBACKGROUND AND PURPOSE:
Recovery after stroke occurs on the basis of specific molecular events. Genetic polymorphisms associated with impaired neural repair or plasticity might reduce recovery from stroke and might also account for some of the intersubject variability in stroke recovery. This study hypothesized that the ApoE ε4 polymorphism and the val(66) met polymorphism for brain-derived neurotrophic factor (BDNF) are each associated with poorer outcome after stroke. Associations with mitochondrial genotype were also explored.
METHODS:
Genotypes were determined in 255 stroke patients who also received behavioral evaluations in the Glycine Antagonist In Neuroprotection (GAIN) clinical trials. The primary outcome measure was recovery during the first month post-stroke, as this is the time when neural repair is at a maximum and so when genetic influences might have their largest impact. Two secondary outcome measures at 3 months post-stroke were also examined.
RESULTS:
Genotype groups were similar acutely post-stroke. Presence of the ApoE ε4 polymorphism was associated with significantly poorer recovery over the first month post-stroke (P = 0.023) and with a lower proportion of subjects with minimal or no disability (modified Rankin score 0-1, P = 0.01) at 3 months post-stroke. Indeed, those with this polymorphism were approximately half as likely to achieve minimal or no disability (18.2%) versus those with polymorphism absent (35.5%). Findings were confirmed in multivariate models. Results suggested possible effects from the val(66) met BDNF polymorphism and from the R0 mitochondrial DNA haplotype.
CONCLUSIONS:
Genetic factors, particularly the ApoE ε4 polymorphism, might contribute to variability in outcomes after stroke
High-resolution clean-sc
No full textIn this paper a high-resolution extension of CLEAN-SC is proposed: HR-CLEAN-SC. Where CLEAN-SC uses peak sources in “dirty maps” to define so-called source components, HR-CLEAN-SC takes advantage of the fact that source components can likewise be derived from points at some distance from the peak, as long as these “source markers” are on the main lobe of the Point Spread Function (PSF). This is very useful when sources are closely spaced together, such that their PSFs interfere. Then, alternative markers can be sought in which the relative influence by PSFs of other source positions is minimised. For those markers the source components better agree with the actual sources, which allows for better estimation of their locations and strengths. This paper outlines the theory needed to understand this approach and discusses applications to 2D and 3D microphone array simulations with closely spaced sources
SC author and illustrator Kate Salley Palmer talking to event attendees
No full textPhotograph of SC author and illustrator Kate Salley Palmer talking to Rita Lewi
Ca-modified Al–Mg–Sc alloy with high strength at elevated temperatures due to a hierarchical microstructure
No full textAl-Mg alloys are normally prone to lose part of their yield and tensile strength at high temperatures due to insufficient thermal stability of the microstructure. Here, we present a Ca-modified Al–Mg–Sc alloy demonstrating high strength at elevated temperatures. The microstructure contains Al4Ca phases distributed as a network along the grain boundary and Al3(Sc,Zr) nano-particles dispersed within the grains. The microstructure evolution and age-hardening analysis indicate that the combination of an Al4Ca network and Sc-rich nano-particles leads to excellent thermal stability even upon aging at 300 °C. The tensile strength of the alloy for temperatures up to 250 °C is significantly improved by an aging treatment and is comparable with the commercial heat-resistant aluminum alloys, i.e., A356 and A319. At a high temperature of 300 °C, the tensile strength is superior to the above-mentioned commercial alloys, even more so when expressed as the specific strength due to the low density of Ca-modified Al–Mg–Sc alloy. The excellent high-temperature strength results from a synergistic effect of solid solution strengthening, grain boundary strengthening and nanoparticle order strengthening.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Novel Aerospace Material
Theatrum anatomicum
No full textAntep.Port. a dos tintas con grab. calc.: "Seiller sc."Texto a dos col., notas a línea tiradaLas h. de grab. calc., la primera: "B. Guillibaud pinxit"; "J. G. Seiller Scaffusianus sculpsit", retrato del autor; las demás: "J.G. Seiller sculpsit", representan partes del cuerpo humanoREBIUN3503354Perg.202012-33-7344C-063-011[ ]4, a6, A-Z6, Aa-Nn6, Oo
SC-Square: Overview to 2021.
No full textThis extended abstract was written to accompany an invited talk at the 2021 SC-Square Workshop, where the author was asked to give an overview of SC-Square progress to date. The author first reminds the reader of the definition of SC-Square, then briefly outlines some of the history, before picking out some (personal) scientific highlights
SC-Square: Overview to 2021.
No full textThis extended abstract was written to accompany an invited talk at the 2021 SC-Square Workshop, where the author was asked to give an overview of SC-Square progress to date. The author first reminds the reader of the definition of SC-Square, then briefly outlines some of the history, before picking out some (personal) scientific highlights
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