1,111 research outputs found
Importanza del profilo farmacologico degli ACE-inibitori nella interpretazione del beneficio clinico: evidenze dallo studio SMILE.
No full textRuolo degli ACE-inibitori nella cardiopatia ischemica: evidenze dal progetto SMILE
System-on-chip Computing and Interconnection Architectures for Telecommunications and Signal Processing
No full textThis dissertation proposes novel architectures and design techniques targeting SoC building blocks for telecommunications and signal processing applications.
Hardware implementation of Low-Density Parity-Check decoders is approached at both the algorithmic and the architecture level. Low-Density Parity-Check codes are a promising coding scheme for future communication standards due to their outstanding error correction performance.
This work proposes a methodology for analyzing effects of finite precision arithmetic on error correction performance and hardware complexity. The methodology is throughout employed for co-designing the decoder. First, a low-complexity check node based on the P-output decoding principle is designed and characterized on a CMOS standard-cells library. Results demonstrate implementation loss below 0.2 dB down to BER of 10^{-8} and a saving in complexity up to 59% with respect to other works in recent literature. High-throughput and low-latency issues are addressed with modified single-phase decoding schedules. A new "memory-aware" schedule is proposed requiring down to 20% of memory with respect to the traditional two-phase flooding decoding. Additionally, throughput is doubled and logic complexity reduced of 12%. These advantages are traded-off with error correction performance, thus making the solution attractive only for long codes, as those adopted in the DVB-S2 standard. The "layered decoding" principle is extended to those codes not specifically conceived for this technique. Proposed architectures exhibit complexity savings in the order of 40% for both area and power consumption figures, while implementation loss is smaller than 0.05 dB.
Most modern communication standards employ Orthogonal Frequency Division Multiplexing as part of their physical layer. The core of OFDM is the Fast Fourier Transform and its inverse in charge of symbols (de)modulation. Requirements on throughput and energy efficiency call for FFT hardware implementation, while ubiquity of FFT suggests the design of parametric, re-configurable and re-usable IP hardware macrocells. In this context, this thesis describes an FFT/IFFT core compiler particularly suited for implementation of OFDM communication systems. The tool employs an accuracy-driven configuration engine which automatically profiles the internal arithmetic and generates a core with minimum operands bit-width and thus minimum circuit complexity. The engine performs a closed-loop optimization over three different internal arithmetic models (fixed-point, block floating-point and convergent block floating-point) using the numerical accuracy budget given by the user as a reference point. The flexibility and re-usability of the proposed macrocell are illustrated through several case studies which encompass all current state-of-the-art OFDM communications standards (WLAN, WMAN, xDSL, DVB-T/H, DAB and UWB). Implementations results are presented for two deep sub-micron standard-cells libraries (65 and 90 nm) and commercially available FPGA devices. Compared with other FFT core compilers, the proposed environment produces macrocells with lower circuit complexity and same system level performance (throughput, transform size and numerical accuracy).
The final part of this dissertation focuses on the Network-on-Chip design paradigm whose goal is building scalable communication infrastructures connecting hundreds of core. A low-complexity link architecture for mesochronous on-chip communication is discussed. The link enables skew constraint looseness in the clock tree synthesis, frequency speed-up, power consumption reduction and faster back-end turnarounds. The proposed architecture reaches a maximum clock frequency of 1 GHz on 65 nm low-leakage CMOS standard-cells library. In a complex test case with a full-blown NoC infrastructure, the link overhead is only 3% of chip area and 0.5% of leakage power consumption.
Finally, a new methodology, named metacoding, is proposed. Metacoding generates correct-by-construction technology independent RTL codebases for NoC building blocks. The RTL coding phase is abstracted and modeled with an Object Oriented framework, integrated within a commercial tool for IP packaging (Synopsys CoreTools suite). Compared with traditional coding styles based on pre-processor directives, metacoding produces 65% smaller codebases and reduces the configurations to verify up to three orders of magnitude
Management of a Multicomorbid Patient with Heart Failure
No full textThe optimal use of sacubitril/valsartan in clinical practice needs further investigation, in particular for patients with multiple comorbidities, as such patients are usually poorly represented in clinical trials. To this end, well-documented case reports may add further evidence to the bulk of "field practice" experience on sacubitril/valsartan. We report here the case of a patient with heart failure with reduced ejection refraction with multiple comorbidities treated with sacubitril/valsartan. Overall, sacubitril/valsartan led to a prompt (within a few months) improvement in LVEF (+15%, from 38 to 53%), without any noticeable adverse events. This therapy also allowed the patient to discontinue furosemide
Paziente con fattori di rischio cardiovascolare multipli.
No full textInquadramento del rischio cardiovascolare globale nel paziente complesso
Ace inhibitor and renin-angiotensin system the cornerstone of therapy for systolic heart failure
No full textHeart failure (HF) can be defined as an abnormality of cardiac structure or function leading to failure of the heart to deliver oxygen at a rate commensurate with the requirements of the metabolizing tissues, despite normal filling pressures (or only at the expense of increased filling pressures) [1]. HF can be also defined, clinically, as a syndrome in which patients have typical symptoms (e.g. breathlessness, ankle swelling, and fatigue) and signs (e.g. elevated jugular venous pressure, pulmonary crackles, and displaced apex beat) resulting from an abnormality of cardiac structure or function. The diagnosis of HF, according to the guidelines of the European Society of Cardiology, can be difficult and is based on a criterion of clinical evaluation, which relies on the clinical history, physical examination and appropriate investigations [2]. For this reason is more important the need to obtain objective evidence of a structural or functional cardiac abnormality that is thought to account for the patient’s symptoms and signs, to secure the diagnosis of HF
Eugenio Battisti e o Antirrenascimento: uma nova proposta historiográfica
No full textL’Antirinascimento, de Eugenio Battisti pertence a uma época de intensas manifestações culturais da vanguarda italiana o que nos leva a ponderar uma insurgente postura política inserida nesta obra frente os congelados esquemas teóricos de crítica e história da arte, ressaltando a vontade do autor da renovação dos paradigmas teóri- cos frente o conservadorismo da historiografia tradicional.
Eugenio Battisti’s L’Antirinascimento belongs to a time of intense cultural manifestations of the Italian avant-garde which leads us to consider an insurgent political stance inserted in this work forward the frozen theoretical schemes of criticism and art history, highlighting the desire of the author of the renewal theoretical paradigm forward the conservatism of traditional historiography
Un caso di gestione medica integrata: angina da sforzo in paziente diabetico
No full textDiabetes mellitus, both of type 1 and 2, is an important risk factor for the development of
atherosclerosis: in diabetic patients vascular atherosclerotic complications are responsible of
approximately 80% of all the deaths. There is no doubt that patients affections originating
from diabetes and coronaropathy remain at high risk. For this reason it is essential to adopt an
aggressive strategy of secondary prevention. We report a case of a patient with multiple risk
factors for cardiovascular diseases: the successful management was due to an integrated approach
that involved the general practitioner and cardiologis
La gestione integrata del rischio cardiovascolare
No full textCardiovascular disease (CVD) is a leading cause of mortality and is responsible for one-third of
all global deaths. Regrettably, surveys of physician’s clinical practice patterns indicate that the
recommendations made in the guidelines are sometimes not implemented and the predefined
goals of therapy for patients with cardiovascular diseases are not achieved. CVD prevention
and management can only be improved through an integrated approach that addresses overall
cardiovascular risk and that involve general practitioners as well as specialists
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