1,720,972 research outputs found

    Other primary peritoneal surface malignancies

    No full text
    Primary peritoneal surface malignancies are rare and aggressive neoplasms.Despite multiple therapeutic strategies that include chemotherapy,aggressive debulking surgery and abdominal wall radiation durable remission remains rare

    Prevention of Peritoneal Carcinomatosis from Colon Cancer in High-Risk Patients.

    No full text
    Introduction: Epidemiological data indicate that peritoneal spread from colorectal cancer is an event that involves 10–15% of patients at the time of primary cancer resection and about 25–50% of patients with recurrent disease, generally leading to death within weeks or months. The study compared the outcome in patients with advanced colonic cancer at high risk of peritoneal metastases without peritoneal or systemic spread, treated with standard colectomy or a more aggressive combined surgical approach. Materials and Methods: The experimental group underwent hemicolectomy, omentectomy, bilateral adnexectomy, hepatic round ligament resection, and appendectomy, followed by HIPEC. The control group comprised patients treated with standard surgical resection during the same period in the same hospital by different surgical teams. Results: Outcome data, morbidity, peritoneal recurrence rate, and overall, and disease-free survival, were compared. Peritoneal recurrence developed in 4% of patients in the experimental group and 22% of controls without increasing morbidity. Actuarial overall survival curves disclosed no significant differences, whereas actuarial disease-free survival curves showed a significant difference between groups. Conclusion: A more aggressive preventive surgical approach combined with HIPEC reduces the incidence of peritoneal recurrence in patients with advanced mucinous colonic cancer and also significantly increases disease-free survival compared with a homogeneous control group treated with a standard surgical approach without increasing morbidity

    Going Beyond Counting First Authors in Author Co-citation Analysis

    Full text link
    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
    corecore