1,721,360 research outputs found
The potential role of Nutlins in the treatment of B-chronic lymphocytic leukemia (B-CLL).
No full text-
Il tricottero Ceraclea fulva e la spugna Ephydatia fluviatilis: un esempio di associazione stabile
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
SV40 and human cancers
No full textAn editorial by the Editor-in-Chief was recently published in this Journal[1] on the association of simian virus 40 (SV40) with specific types of human cancers: brain and bone tumors, lymphomas and mesotheliomas. While we agree with the author of the editorial that the association of SV40 with human tumors does not establish, at present, a causative link and that it is clearly premature to label SV40 as a human carcinogen, nevertheless we would like to point out some aspects of the topic that, in our opinion, have been omitted or not properly considered in the editorial.
1. The copy number of the SV40 genomes in human lymphoproliferative disorders and PBMC specimens was measured and was estimated, by semiquantitative PCR, to be between 10-4 and 10-2 genome equivalents per cell.[2] This result was confirmed by in situ hybridization experiments,[3] which detected 1 out of 250 cells positive for SV40 DNA in human lymphoblastoid B-cells, a value fitting the results of the previous analysis.[2] Recent contributions[4][5][6] have shown that human mesothelial cells, transformed by SV40 and expressing SV40 large T antigen (Tag), generate an autocrine-paracrine loop that may recruit SV40 Tag-negative cells into proliferation in SV40-associated human tumors. Thus, it is conceivable that not every cell in the tumor needs to express SV40 Tag in order to participate in tumor growth.
2. The two largest epidemiological studies on the incidence of brain tumors in poliovirus vaccinated individuals, carried out in the United States and in the former East Germany, were discontinued about 25 years ago[7] and 15 years ago,[8] respectively, just when a trend towards a greater incidence of certain brain tumors was observed in cohorts of vaccinated persons
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
TRAIL and osteoprotegerin: a role in endothelial physiopathology?
No full textIncreasing experimental evidence suggests that both tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its soluble decoy receptor osteoprotegerin (OPG) are involved in vascular biology. In particular, emerging data indicate that recombinant soluble TRAIL may act as a molecule with potential anti-inflammatory activity in vascular physiopathology. Conversely, the presence of leukocytes expressing membrane-bound TRAIL in atherosclerotic lesions might be involved in the destabilization of atherosclerotic plaques by inducing apoptotic cell death of vascular smooth muscle cells in an inflammatory milieu. Also OPG seems to be involved in vascular homeostasis, by acting in a paracrine or autocrine manner as a survival factor for endothelial cells. However, an increased production of OPG may have a role in the development of vascular dysfunction likely by multiple potential mechanisms, not only related to its ability to neutralize TRAIL-activity but also mediated by its heparin-binding domain. In this review we have summarized and discussed both in vitro and in vivo data that suggest potential roles of TRAIL and OPG in vascular physiopathology. Further studies are needed to address how the TRAIL/OPG interaction, their reciprocal balance and/or interplay affect vascular biology in order to design innovative therapeutic strategies in vascular diseases
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
