179,623 research outputs found
ATP6V0A1 polymorphism and microRNA-637: A pathogenetic role for microRNAs in essential hypertension at last?
No full textCarcassi C., Porcella R., Manca M.L., La Nasa G., Leone A.L., Boero R., Cerimele D., Contu L.: Analisi del DNA della regione HLA nel Sarcoma di Kaposi classico Rivista di Oncologia, 1-2: 1-5, 1987
No full textEvaluation of Residual Kidney Function during Once-Weekly Incremental Hemodialysis
No full textBackground: The initial once-weekly administration of incremental hemodialysis to patients with residual kidney function (RKF) has recently attracted considerable interest. Methods: The aim of our study was to assess the performance of a series of different methods in measuring serum urea nitrogen and serum Cr (sCr) RKF in patients on once-weekly hemodialysis (1WHD). Evaluations were carried out by means of 24-h predialysis urine collection (Kr-24H) or 6-day inter-dialysis collection (Kr-IDI) and estimation of glomerular filtration rate based on (KrSUN + KrsCr)/2 for the purpose of identifying a simple reference calculation to be used in assessing RKF in patients on 1WHD dialysis. Ninety-five urine samples were collected from 12 1WHD patients. A solute solver urea and Cr kinetic modeling program was used to calculate residual urea and Cr clearances. Mann-Whitney U test, Pearson's correlation coefficient (R), and linear determination coefficient (R-2) were used for statistical analysis. Results: 1WHD patients displayed a mean KrSUN-IDI of 4.5 +/- 1.2 mL/min, while KrSUN-24H corresponded to 4.1 +/- 0.9 mL/min, mean KrsCr-IDI to 9.1 +/- 4.0 mL/min, and KrsCr 24H to 8.9 +/- 4.2 mL/min, with a high regression between IDI and 24-h clearances (for IDI had R-2 = 0.9149 and for 24H had R-2 = 0.9595). A good correlation was also observed between KrSUN-24H and (KrSUN + KrsCR/2) (R-2 = 0.7466, p < 0.01. Discussion: Urine collection over a 24-h predialysis period yielded similar results for both KrSUN and KrsCr compared to collection over a longer interdialytic interval (KrSUN + KrsCr)/2 could be applied to reliably assess RKF in patients on 1WHD. Conclusion: The parameters evaluated are suitable for use as a routine daily method indicating the commencement and continued use of the 1WHD Incremental Program
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Citizens’ involvement in risk management: the view of community members
No full textBackground: Industrial risk management plays a central role in creating supportive environments for health. This paper examines the community's trust in citizens' involvement in risk management, investigating differences among settings exposed to different levels of industrial risk. Additionally it aims to identify the social demographic characteristics of those manifesting high trust in citizens' involvement in risk management. Methods: The survey, performed in Sardinia between 2006 and 2007, was carried out in three representative areas this Region: a metropolitan area, an industrial area, and a rural area. A questionnaire was administered to 1,104 citizens to investigate community's trust in citizens as risk managers. Results: Trust in citizens' involvement in risk management was expressed to a greater extent by residents in the rural area, by those with a high level of education, and by older women. The expression of high trust in citizens' involvement was more likely in older higher-educated women (58-69%) than in lower educated ones (52-63%) and, to a lesser extent, in both genders with higher education (42-51%). Conclusions: A consistent number of the community's members would entrust citizens with risk management not only in areas with a severe industrial impact, but also in those areas where industrial risk is considered of limited entity. The community's tendency towards citizens' involvement in risk management appears to be an intrinsic trait of the community itself rather than an attitude triggered by a specific problem. Older women, and adults with higher education can be recognised as categories in which potential early adopters of risk management can be easily found
Circulating microRNAs as potential biomarkers of coronary artery disease: a promise to be fulfilled?
No full textInvited Response on: Letter-to-the-Editor: Defining the Inframammary Fold by Liposuction: An Essential Tool in Aesthetic Shaping of the Reconstructed Breast—Technique and Long-Term Results in a Series of Patients
No full textWe read with interest the commentary by Atiyeh et al. to our paper ‘‘Defining the Inframammary Fold by Liposuction: An Essential Tool in Aesthetic Shaping of the Reconstructed Breast. Technique and Long-Term results in a Series of Patients’’. We are grateful for their interest in our work and their constructive comments on the important role of a well-defined inframammary fold as a critical visual landmark for breast aesthetic
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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