1,722,679 research outputs found

    Why excitatory amino acids and the cerebral cortex?

    No full text
    NRC publication: Ye

    The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 up-regulation on prepulse inhibition of the startle reflex in adult rats

    No full text
    The main glutamate transporter GLT-1 is responsible for clearing synaptically released glutamate from the extracellular space and contributes to shape glutamatergic transmission. Recently, it has been shown that ceftriaxone (CEF)-induced GLT-1 up-regulation is associated to an impairment of the prepulse inhibition (PPI) of the startle reflex, a simple form of information processing that is reduced in schizophrenia, and determines a strong reduction of hippocampal mGluR2/3-dependent long term depression (LTD). Here, we tested the hypothesis that administration of the mGluR2/3 agonist LY379268 blocks the effect of GLT-1 up-regulation on PPI of the startle. We showed that LY379268 (1 mg/Kg) administration prevented PPI alterations associated to GLT-1 up-regulation, suggesting that CEF-induced PPI impairment was mGluR2/3-dependent. In addition, we demonstrated that CEF-induced GLT-1 up-regulaton did not alter the expression of mGluR2/3, and that it occurred at sites of mGluR2/3 expression. These results indicate a novel mechanism by which GLT-1 up-regulation modulates PPI of the startle

    A taxonomic revision of the Siler montanum group (Apiaceae) in Italy and the Balkan Peninsula

    Full text link
    Abstract: A morphometric-based taxonomic revision of the Siler montanum group (Apiaceae) from Italy and the Balkan Peninsula was carried out. Multivariate and univariate analyses were performed on 47 morphological characters including seven ratios, and based on the study of 328 dried herbarium specimens. According to our results, the characters employed in the study revealed their suitability as key characters for the examined taxa. A taxonomic treatment was presented and a new diagnostic key to the S. montanum group is also provided for Italy and Balkan Peninsula. Ten taxa were recognized within the group, and among them three new subspecies were described: S. montanum subsp. apuanum, S. montanum subsp. corrasianum and S. montanum subsp. ogliastrinum. Furthermore, three new combinations were proposed: S. zernyi subsp. laeve, S. zernyi subsp. ochridanum and S. montanum subsp. stabianum. Six names were lectotypified: Laserpitium garganicum var. balcanicum, L. garganicum var. laeve, L. garganicum var. scabrum, L. siculum var. stabianum, L. siler var. ovalifolium and Ligusticum garganicum. Occurrences were confirmed for Siler zernyi subsp. zernyi in Greece and S. zernyi subsp. laeve in North Macedonia. Occurrences were excluded for S. montanum subsp. garganicum in Greece and North Macedonia and S. montanum subsp. siculum in C and S Italy. Citation: Conti F., Bartolucci F., Bacchetta G., Pennesi R., Lakušić D. & Niketić M. 2021: A taxonomic revision of the Siler montanum group (Apiaceae) in Italy and the Balkan Peninsula.-Willdenowia 51: 321-347. Version of record first published online on 16 November 2021 ahead of inclusion in December 2021 issue
    corecore