1,721,011 research outputs found
YOU CAN ARRIVE! Proposte per l’accessibilità delle Rive di Trieste
No full textQuesto lavoro di tesi ha come obiettivo la redazione e l’applicazione di un PEBA alla città di Trieste. YOU CAN ARRIVE è il titolo scelto per il progetto, un gioco di parole molto significativo: attraverso queste proposte sarebbe davvero possibile permettere a tutti di poter accedere alle Rive, asse d’affaccio sul mare della città
L'accessibilità, requisito ambientale per la sostenibilità sociale ed economica del patrimonio esistente. Esperienze di ricerca.
No full text
Inhibition of Parvovirus B19 replication by Cidofovir in extendedly exposed erythroid progenitor cells
No full textHuman parvovirus B19 (B19V) commonly induces self-limiting infections but can also cause severe clinical manifestations in patients with underlying hematological disorders or with immune system deficits. Currently, therapeutic options for B19V entirely rely on symptomatic and supportive treatments since a specific antiviral therapy is not yet available. Recently a first step in the research for active compounds inhibiting B19V replication has allowed identifying the acyclic nucleoside phosphonate cidofovir (CDV). Herein, the effect of CDV against B19V replication was characterized in human erythroid progenitor cells (EPCs) cultured and infected following different experimental approaches to replicate in vitro the infection of an expanding erythroid cell population in the bone marrow. B19V replication was selectively inhibited both in infected EPCs extendedly exposed to CDV 500 μM (viral inhibition 82%) and in serially infected EPCs cultures with passages of the viral progeny, constantly under drug pressure (viral inhibition >99%). In addition, a potent inhibitory effect against B19V (>92%) was assessed in a short-term infection of EPCs treated with CDV 500 μM prior to viral infection. This enhanced anti-B19V activity of CDV could be ascribed both to the increased intracellular drug concentration achieved by extended exposure, and to a progressive reduction in efficiency of the replicative process within treated EPCs population
Inhibition of Parvovirus B19 replication by Cidofovir in extendedly exposed erythroid progenitor cells
No full textHuman parvovirus B19 (B19V) commonly induces self-limiting infections but can also cause severe clinical manifestations in patients with underlying hematological disorders or with immune system deficits. Currently, therapeutic options for B19V entirely rely on symptomatic and supportive treatments since a specific antiviral therapy is not yet available. Recently a first step in the research for active compounds inhibiting B19V replication has allowed identifying the acyclic nucleoside phosphonate cidofovir (CDV). Herein, the effect of CDV against B19V replication was characterized in human erythroid progenitor cells (EPCs) cultured and infected following different experimental approaches to replicate in vitro the infection of an expanding erythroid cell population in the bone marrow. B19V replication was selectively inhibited both in infected EPCs extendedly exposed to CDV 500 μM (viral inhibition 82%) and in serially infected EPCs cultures with passages of the viral progeny, constantly under drug pressure (viral inhibition >99%). In addition, a potent inhibitory effect against B19V (>92%) was assessed in a short-term infection of EPCs treated with CDV 500 μM prior to viral infection. This enhanced anti-B19V activity of CDV could be ascribed both to the increased intracellular drug concentration achieved by extended exposure, and to a progressive reduction in efficiency of the replicative process within treated EPCs population
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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