1,722,044 research outputs found
DNA as a vehicle for the self-assembly model of computing
No full textA DNA version of the self-assembly model of computing, feasible using currently available laboratory techniques, is proposed. Input signals are coded into unmethylated and methylated oligonucleotides which then hybridize with a backbone that contains complementary sequences. Different input signal patterns are thus represented as DNA duplexes with distinctly different conformational dynamics, in particular different equilibria of B and Z DNA. The pattern classification activity of the system is mediated by the interactions that lead to the secondary structural organization. Circular dichroism may be used for readout
Molecular Computing with Artificial Neurons
No full textToday's computers are built up from a minimal set of standard pattern recognition operations. Logic gates, such as NAND, are common examples. Biomolecular materials offer an alternative approach, both in terms of variety and context sensitivity. Enzymes, the basic switching elements in biological cells, are notable for their ability to discriminate specific molecules in a complex background and to do so in a manner that is sensitive to particular milieu features and indifferent to others. The enzyme, in effect, is a powerful context sensitive pattern recognizer. We describe a tabletop pattern processor that in a rough way can be analogized to a neuron whose input-output behavior is controlled by enzymatic dynamics
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Portrait of Conrad M. von Blucher
No full textPortrait of Conrad M. von Bluche
Enzymatic pattern processing
No full textA table-top prototype has been constructed that uses the enzyme malate dehydrogenase to recognize input signal patterns. The device is controlled by the enzyme in response to injection of Mg2+ used as a signaling substance. Output is monitored spectroscopically. If Mg2+ is injected along either of two signal lines (i.e., if the input signal pattern is 10 or 01) the device emits an output of 1. Injection along neither or both lines results in an output of 0. The enzyme in effect is used as a transform that converts the linearly inseparable exclusive-or problem into a linearly separable problem
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Conrad M. von Blucher in the varsity band
No full textConrad M. von Blucher in the varsity ban
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Conrad M. Blucher's biography created for J.S. Naismith
No full textConrad M. Blucher's biography created for J.S. Naismit
Conrad M. STIBBE, Trebenishte. The Fortunes of an Unusual Excavation.
No full textProst Francis. Conrad M. STIBBE, Trebenishte. The Fortunes of an Unusual Excavation. . In: L'antiquité classique, Tome 73, 2004. p. 585
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