1,724,325 research outputs found
Read the book and see the film?:the consumption of different versions of cultural goods
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Mapping disease genes using the Malecot model for allelic association and the beta model for linkage
No full textAlthough there are a number of alternative methods for mapping oligogenes the beta model implemented in the program BETA has been shown to be amongst the more powerful. The model has been applied to a sample of 240 asthma and atopy families typed for markers on chromosome 12 and the results suggest at least one asthma determinant may be present. The Malecot model implemented in the program ALLASS has yet to be applied to oligogenes but has been effective in the localization of major genes by exploiting the relationship between linkage disequilibrium and distance from the gene. Extension to oligogenes would seem to be a profitable way forward
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Linkage disequilibrium mapping using single nucleotide polymorphisms--which population?
No full textThere is considerable interest in the potential of single nucleotide polymorphisms (SNPs) for mapping complex traits which are determined by genes of small individual effect (oligogenes). It is thought likely that many oligogenes are themselves common polymorphisms, perhaps biallelic, for which there is effectively neutral selection reflected in late age of onset. The extent of detectable linkage disequilibrium between SNP x SNP pairs and SNP x oligogene pairs is of considerable interest, particularly in the context of identifying 'favourable' populations. Unfortunately data are sparse and few populations have been extensively sampled. Polymorphisms with the appropriate characteristics that have been studied are blood groups in the Rhesus and MNS systems for which there are extensive data on four pairs of biallelics. These might be regarded as surrogates for SNP-SNP or SNP-oligogene pairs. By developing and applying an approach, previously used for major genes, to evaluate association (rho) in SNP haplotypes, it is evident that, with some exceptions, there is little difference between isolates and large populations. Furthermore it is apparent that there is useful linkage disequilibrium even for the MN-Ss locus pair (0.195 cM apart), in both large populations and isolates. This is somewhat more favourable to linkage disequilibrium mapping than a recent simulation suggests.</p
Linkage disequilibrium maps: 'blocks' without haplotyping and application to disease mapping.
No full textMapping disease genes using the Malecot model for allelic association and the β model for linkage
No full textAlthough there are a number of alternative methods for mapping oligogenes the β model implemented in the program BETA has been shown to be amongst the more powerful. The model has been applied to a sample of 240 asthma and atopy families typed for markers on chromosome 12 and the results suggest at least one asthma determinant may be present. The Malecot model implemented in the program ALLASS has yet to be applied to oligogenes but has been effective in the localization of major genes by exploiting the relationship between linkage disequilibrium and distance from the gene. Extension to oligogenes would seem to be a profitable way forward.</p
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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