118,376 research outputs found
Dr. Ruggero Cobelli
No full textCobelli, Ruggero (1838-1921).
Medico, già assistente di fisiologia nell\u27Università di Padova, fratello di Cobelli Giovanni (1849-1937).
Titolo manoscritto sul recto, dove è riportato anche: Folgaria 26 luglio 1897. Nota manoscritta sul verso: Dr. Ruggero Cobelli da Rovereto.
1 fotografia : aristotipo? ; 162 x 120 mm.
Vai alla scheda bibliografica: https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma99001548820020604
Prof. Gio. de Cobelli - verso
No full textBotanico: Cobelli, Giovanni (1849-1937).
Professore di storia naturale a Rovereto, fratello di Cobelli Ruggero (1838-1921).
Titolo manoscritto sul recto, dove compare anche la data: 1898.
Nota manoscritta sul verso: Prof. Giovanni de Cobelli (1898) Rovereto.
Montata su cartoncino 106 x 66 mm.
1 fotografia : albumina ; 94 x 65 mm.
Vai alla scheda bibliografica: https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma99001503521020604
Prof. Gio. de Cobelli - recto
No full textBotanico: Cobelli, Giovanni (1849-1937).
Professore di storia naturale a Rovereto, fratello di Cobelli Ruggero (1838-1921).
Titolo manoscritto sul recto, dove compare anche la data: 1898.
Nota manoscritta sul verso: Prof. Giovanni de Cobelli (1898) Rovereto.
Montata su cartoncino 106 x 66 mm.
1 fotografia : albumina ; 94 x 65 mm.
Vai alla scheda bibliografica: https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma99001503521020604
Models for measuring hepatic glucose production from labelled IVGTT
No full textIn the line of the minimal modelling strategy, we present various modelling attempts to measure hepatic glucose production during a labelled intravenous glucose tolerance test (labelled IVGTT). We propose a physiological model which allows to reconstruct by deconvolution a profile of hepatic glucose production which is more reliable than those obtained with simpler models. The model presented incorporates the most recent information on the influence of insulin on glucose kinetics and allows recovery of a more physiological prediction of hepatic response during the IVGTT
Parameter estimation of biological stochastic compartmental models.
No full textIn this paper linear time invariant biological compartmental models are considered, in which the transfer rate constants are assumed to be stochastic variables
On the identification by filtering techniques of a biological n-compartment model in which the transport rate parameters are assumed to be stochastic processes.
No full textIn this paper biological compartmental models are considered which take into account the intrinsic randomness of the transport rate parameters and their possible variability in time. An identification procedure is presented for the estimation of the stochastic processes representing the transport rate parameters of a compartmental model from a noisy input-output experiment. The problem is formulated in terms of nonlinear filtering. A simple model is discussed for the case in which the transport rate parameters are independent of each other. The possibility of testing possible important features of the behavior of the transport rate parameters is also evidenced
V-A and A-V modes in whole body and regional kinetics: domain of validity from a physiological model
No full textIn turnover studies, both at whole body and regional level, sources of tracer and tracee are in general nonidentical thus resulting in nonuniformity of specific activity (SA). Guidelines are available in literature to deal with the heterogeneous SA problem, and either the V-A or A-V modes, based on the arterial and mixed venous blood SA, respectively, have been recommended for different substrates. In particular, the A-V mode is considered the method of choice for studying lactate, amino acids, free fatty acid, etc. Guidelines are based on specific models chosen to describe kinetic and circulatory events of the substance under study but are often conflicting. A unitary physiological framework to understand assumptions of various models is also lacking. In this paper, we first review these models to assess their domain of validity. In particular, we point out major drawbacks that relate to the tissue compartment being treated as a lumped well-mixed pool with a single SA value. We then attempt to handle the nonuniform tissue SA by employing a more physiological model. The tissue system is thought to be made up of elementary units connected in parallel and categorized according to their functional ability to affect incoming SA. Potential changes of SA within individual units are examined. Thus each tissue unit may provide a different contribution to the overall change in SA, as measured in mixed venous blood. A spatial profile of SA is also identified both along the direction of blood flow and transversely toward the inner cellular space. This distributed model allows assessment of the domain of validity of V-A and A-V modes. We show that, in general, the V-A mode underestimates the production rate both at whole body and regional level, whereas the A-V mode can either under- or overestimate it
Generic medicines non-adoption: investigating the perceptions and attitudes of customers and the role of health professionals’ service network
No full textAlthough generic medicines can be beneficial to patients and the healthcare system thanks to the considerably lower costs, in Italy the market penetration of these products is lower than in other European countries. Only a few partial studies have been conducted to investigate the reasons of such a low penetration rate. A lack of the information given to patients about these products emerged from these studies.
The purpose of this paper is to give a further contribution to this stream of research by investigating the motivations behind Italian patients’ resistance to buy generic medicines instead of the branded ones. More specifically the (potential) influence of health professionals’ information and advice in changing customers’ attitudes towards generic medicines and their behavior is studied.
In order to collect empirical evidence, a survey was conducted among a sample of Italian patients who have not adopted generics so far. 95 questionnaires were collected and analyzed, highlighting that interviewees tend to overestimate generics’ disadvantages and to underestimate generics’ benefits. Moderator effects of patients’ age and education are identified, as well. More interestingly the findings demonstrate the potential contribution that general practitioners could give to support generic medicines’ adoption. The results will be discussed and practical implications will be derived
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