1,720,966 research outputs found
Evaluation of the cardiac toxicity of N-methyl-glucamine antimoniate in dogs with naturally occurring leishmaniasis
No full textRitmo idioventricolare accelerato nel cane: 9 casi clinici
No full textThe clinical, electrocardiographic and diagnostic tests findings, and outcome
of 9 dogs with accelerated idioventricular rhythm (AIVR) are described. Different systemic
disorders including septicaemia of various origin, acute pancreatitis, lymphoblastic leukaemia,
discospondilitis, and viper bite were diagnosed. One dog with seizures developed AIVR
during anaesthesia to perform a CT scan. Elevated serum concentration of cTnI were found in
all the five dogs in which this cardiac biomarker was determined. Conversion to sinus rhythm
was obtained in all dogs following supportive therapy for the primary disorder. A specific antiarrhythmic drug (lidocaine) was employed in only 2 dogs
Serum cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension.
Full text linkBackground: Pulmonary hypertension (PH) is a disease condition leading to right‐sided cardiac hypertrophy and, eventually, right‐sided heart failure. Cardiac troponin I (cTnI) is a circulating biomarker of cardiac damage.
Hypothesis: Myocardial damage can occur in dogs with precapillary and postcapillary PH.
Animals: One hundred and thirty‐three dogs were examined: 26 healthy controls, 42 dogs with mitral valve disease (MVD) without PH, 48 dogs with pulmonary hypertension associated with mitral valve disease (PH‐MVD), and 17 dogs with precapillary PH.
Methods: Prospective, observational study. Serum cTnI concentration was measured with a commercially available immunoassay and results were compared between groups.
Results: Median cTnI was 0.10 ng/mL (range 0.10–0.17 ng/mL) in healthy dogs. Compared with the healthy population, median serum cTnI concentration was increased in dogs with precapillary PH (0.25 ng/mL; range 0.10–1.9 ng/mL; P < .001) and in dogs with PH‐MVD (0.21 ng/mL; range 0.10–2.10 ng/mL; P < .001). Median serum cTnI concentration of dogs with MVD (0.12 ng/mL; range 0.10–1.00 ng/mL) was not significantly different compared with control group and dogs with PH‐MVD. In dogs with MVD and PH‐MVD, only the subgroup with decompensated PH‐MVD had significantly higher cTnI concentration compared with dogs with compensated MVD and PH‐MVD. Serum cTnI concentration showed significant modest positive correlations with the calculated pulmonary artery systolic pressure in dogs with PH and some echocardiographic indices in dogs with MVD and PH‐MVD.
Conclusions and Clinical Importance: Serum cTnI is high in dogs with either precapillary and postcapillary PH. Myocardial damage in dogs with postcapillary PH is likely the consequence of increased severity of MVD
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
