196,020 research outputs found
The building stones of Pienza (Tuscany, Italy)
No full textPienza, a fifteenth-century town in Tuscany, Italy, is renowned as a prime example of Renaissance urbanism. Constructed by Pope Pius II, the town was designed by the esteemed architect Bernardo Rossellino to embody an ideal city centered around a grand square, Piazza Pio II. This study focuses on
identifying and characterizing the stones used in Pienza's main buildings and understanding their decay forms. Through XRF and XRD analyses, the chemical and mineralogical characteristics of the main
identified litologies (Pienza sandstones and Bioclastic calcirudites) have been determined. Microscopic observations aided in studying thin sections, while physical and mechanical properties of the stones
were also assessed. The findings have led to the proposal of an geo-lithological itinerary to showcase the building stones of the most remarkable monuments and palaces of the Pienza center, and highlight the locations of their quarrying areas. This research aims to contribute to the knowledge and valorization of Pienza's architectural heritage
Meccanizzazione delle operazioni di raccolta degli strobili di pino domestico (Pinus pinea L.). Nota 2 - Risultati produttivi e prime valutazioni degli effetti delle vibrazioni sulle piante
No full textMeccanizzazione delle operazioni di raccolta degli strobili di pino domestico (Pinus pinea L.). Nota 1 - Macchine ed attrezzature, cantieri e organizzazione del lavoro
No full textThe basic domain in HIV-1 Tat protein as a target for polysulfonated heparin-mimicking extracellular Tat antagonists
No full textHeparin binds extracellular HIV-1 Tat protein and modulates its HI long terminal repeat (LTR)-transactivating activity (M. Rusnati, D. Coltrini, P. Oreste, G. Zoppetti, A. Albini, D. Noonan, F. d'Adda di Fagagna, M. Giacca, and M. Presta (1997) J. Biol. Chem. 272, 11313-11320). On this basis, the glutathione S-transferase (GST)-Tat(R49/52/53/55/56/57A) mutant, in which six arginine residues within the basic domain of Tat were mutagenized to alanine residues, was compared with GSTTat for its capacity to bind immobilized heparin. Dissociation of the GST-Tat(R49/52/53/55/56/57A) · heparin complex occurred at ionic strength significantly lower than that required to dissociate the GST-Tat-heparin complex. Accordingly, heparin binds immobilized GST-Tat and GSTTat(R49/52/53/55/56/57A) with a dissociation constant equal to 0.3 and 1.0 μM, respectively. Also, the synthetic basic domain Tat-(41-60) competes with GST-Tat for heparin binding. Suramin inhibits [3H]heparin/Tat interaction, 125I-GST-Tat internalization, and the LTR-transactivating activity of extracellular Tat in HL3T1 cells and prevents 125I-GST-Tat binding and cell proliferation in Tat-overexpressing T53 cells. The suramin derivative 14CPNU 145156E binds immobilized GST-Tat with a dissociation constant 5 times higher than heparin and is unable to bind GST-Tat(R49-52/53/55/56/57A). Although heparin was an antagonist more potent than suramin, modifications of the backbone structure in selected suramin derivatives originated Tat antagonists whose potency was close to that shown by heparin. In conclusion, suramin derivatives bind the basic domain of Tat, prevent Tat/heparin and Tat/cell surface interactions, and inhibit the biological activity of extracellular Tat. Our data demonstrate that tailored polysulfonated compounds represent potent extracellular Tat inhibitors of possible therapeutic value
The basic domain in HIV-1 Tat protein as a target for polysulfonated heparin-mimicking extracellular Tat antagonists.
No full textHeparin binds extracellular HIV-1 Tat protein and modulates its HIV long terminal repeat (LTR)-transactivating activity (M. Rusnati, D. Coltrini, P. Oreste, G. Zoppetti, A. Albini, D. Noonan, F. d'Adda di Fagagna, M. Giacca, and M. Presta (1997) J. Biol. Chem. 272, 11313-11320). On this basis, the glutathione S-transferase (GST)-TatR49/52/53/55/56/57A mutant, in which six arginine residues within the basic domain of Tat were mutagenized to alanine residues, was compared with GST-Tat for its capacity to bind immobilized heparin. Dissociation of the GST-TatR49/52/53/55/56/57A.heparin complex occurred at ionic strength significantly lower than that required to dissociate the GST-Tat.heparin complex. Accordingly, heparin binds immobilized GST-Tat and GST-TatR49/52/53/55/56/57A with a dissociation constant equal to 0.3 and 1.0 microM, respectively. Also, the synthetic basic domain Tat-(41-60) competes with GST-Tat for heparin binding. Suramin inhibits [3H]heparin/Tat interaction, 125I-GST-Tat internalization, and the LTR-transactivating activity of extracellular Tat in HL3T1 cells and prevents 125I-GST-Tat binding and cell proliferation in Tat-overexpressing T53 cells. The suramin derivative 14C-PNU 145156E binds immobilized GST-Tat with a dissociation constant 5 times higher than heparin and is unable to bind GST-TatR49/52/53/55/56/57A. Although heparin was an antagonist more potent than suramin, modifications of the backbone structure in selected suramin derivatives originated Tat antagonists whose potency was close to that shown by heparin. In conclusion, suramin derivatives bind the basic domain of Tat, prevent Tat/heparin and Tat/cell surface interactions, and inhibit the biological activity of extracellular Tat. Our data demonstrate that tailored polysulfonated compounds represent potent extracellular Tat inhibitors of possible therapeutic value
New Heterocyclic Analogs of Suramin with bFGF Inhibiting Activity. Synthesis, SAR and Possible Mode of Action
No full textSome heterocyclic analogs of suramin with potent and selective basic fibroblast growth factor (bFGF) complexing activity have been synthesized. The possible mode of action of these compounds, deduced on the basis of SAR, biological properties and molecular modeling studies, entails a unique bidentate binding of the ligands to both the heparin and receptor binding sites of the growth facto
Nemorubicin: A doxorubicin-like structure with a novel mechanism of action different from anthracyclines.
No full textDr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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