1,721,333 research outputs found
EFFECT OF BIMATOPROST ON PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA OR OCULAR HYPERTENSION WHO ARE NON RESPONDERS TO LATANOPROST
No full textPurpose: To test the efficacy of bimatoprost 0.03% 2D for lowering intraocular pressure (IOP) in patients affected by primary open-angle glaucoma or ocular hypertension who did not respond to treatment with latanoprost 0.005% 2D. Design: Prospective, randomized clinical trial with a cross over design (two 30-day treatment phases with a 30-day washout phase in between). Participants: Fifteen patients were enrolled. Random allocation to treatment to a single eye only of every subject. Eligibility criteria: (1) IOP > 22 mmHg in both eyes on current treatment (on three separate readings > 24 hours apart), (2) angle wide open in both eyes, (3) no pseudoexfoliation and/or pigment dispersion in either eye, (4) documented medical history consistent with < 10% IOP decrease in both eyes on 2-month treatment with latanoprost 0.005% every day. Method: The following variables were measured at each study visit: (1) IOP (Goldmann applanation tonometry, 5 readings, 8 AM, 12 noon, 4 Pm, 8 Pm, and 12 midnight); (2) visual acuity (Early Treatment of Diabetic Retinopathy Study chart, logarithm of the minimum angle of resolution); (3) estimate of conjunctival hyperemia based on 5 standard photographs (graded as "none" "trace," "mild," "moderate," and "severe"). Main Outcome Measure: IOP. Results: IOP data (mean and standard deviation) were the following: baseline = 24.7 +/- 0.9 mmHg, after washout = 24.8 +/- 1.1 mmHg, after latanoprost phase = 24.1 +/- 0.9 mmHg, after bimatoprost phase = 18.1 +/- 1.7 mmHg. IOP on bimatoprost proved lower than both baseline (P < 0.0001) and latanoprost (P = 0.0001). Thirteen of 15 patients showed a greater than or equal to 20% IOP decrease with bimatoprost treatment. None of the 15 patients showed a greater than or equal to 20% decrease of IOP after 30 days of latanoprost treatment. No significant IOP changes were observed in the fellow untreated eye in each patient throughout the study. Trace-to-mild conjunctival hyperemia was recorded more often with bimatoprost phase (P = 0.035). Conclusions. Thirteen of 15 patients, who were nonresponders to latanoprost, 0.005%, 2D, were successfully treated with bimatoprost, 0.03%, 2D. Bimatoprost treatment was associated with a higher incidence of trace-to-mild conjunctival hyperemia than latanoprost
Deep sclerectomy without absorbable implant and with unsutured superficial flap: Prospective randomized clinical trial vs. trabeculectomy with releasable sutures
No full textEffect of 0.03% bimatoprost on patients non-responders to 0.005% latanoprost: A cross-over study
No full textThe effects of food or cover removal on spacing patterns and habitat use in roe deer (Capreolus capreolus)
No full textThe knowledge of the ability of a species to adapt to a human-altered environment is important for developing wildlife management plans and, in turn, for conservation of the species. Radio-tracking was used to examine the effects of partial food or cover removal (owing to agricultural changes) on the spacing patterns and habitat use of adult roe deer Capreolus capreolus in a mixed wood/agricultural Mediterranean area, during spring-summer 1996-97. For both sexes, there were no changes in home-range and core-area sizes, or in inter-fix distances, after food (field ploughing) or cover (crop harvesting) removal. After food removal, both sexes shifted their home ranges and core areas, spending more time in woodland and less time in the ploughed fields. This suggests a change in feeding habits. In addition, similar responses by males and females indicate that their energetic requirements are comparable during the territorial/reproductive period. After removal of cover, males neither shifted their home ranges and core areas nor changed their habitat use, whereas females responded with significant shifts (by c. 90%) of the core area, and a significant decrease in the proportion of daytime spent in the harvested fields. Thus, crop harvesting in this period (May-June) has different effects on the two sexes, with adult females being much less tolerant than males. Differential responses to cover removal were related to the different security requirements of the two sexes around the period of parturition
Deep sclerectomy without absorbable implants and with unsutured scleral flap: prospective, randomised 2-year clinical trial vs trabeculectomy with releasable sutures
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