1,721,019 research outputs found
MECCANISMI D'AZIONE DELLE TOSSINE FUNGINE E POSSIBILITÀ DI COLLEGAMENTO CON GLI INTERVENTI CLINICI.
No full textLa diagnosi differenziale precoce domiciliare ed ospedaliera delle intossicazioni da funghi richiede conoscenze e competenze che spaziano dalla guardia micologica a metodologie di laboratorio, da semplici-rapide e sofisticate-lente, nell’intento di aprire in tempo una finestra terapeutica sufficientemente certa e ampia, non prima di aver risolto il problema pressante del “se fare e/o nonfare”. Al di là delle diagnosi di certezza, nei casi di intossicazione dubbia o sospetta, il ricovero può non essere necessario purché ambulatorialmente venga praticato un attento monitoraggio della sintomatologia e del quadro bioumorale nel corso del tempo di latenza che rimane l’accertamento diagnostico fondamentale purché non troppo tardivo
Analisi epistemologica delle esperienze di premorte galileianamente "sensate e dimostrate": scienza e coscienza al confine tra fisica e metafisica.
No full textFARMACOTOSSICOLOGIA DELLA CUMARINA E DEI SUOI DERIVATI SOSTITUITI.
No full textContenuto della monografia: Biosynthesis and distribution of coumarins in the plant; Effetti altitudinali sugli scambi gassosi e la produzione di cumarine in Heracleum sphondylium L.; Domestication of australian Psoralea (Leguminosae) for furocoumarin production; Sintesi di cumarine e furocumarine naturali e modificate; Mass spectrometry in structural characterization of coumarinic systems; Applicazione della spettroscopia NMR nell'identificazione di strutture cumariniche; Analisi di cumarine in matrici cosmetiche non trattate mediante spettroscopia di fluorescenza; Cenni storici sullo sviluppo delle ricerche sulle furocumarine; Proprietà fotochimiche delle furocumarine; Proprietà fotobiologiche delle furocumarine; Farmacotossicologia della cumarina e dei suoi derivati sostituiti; Le furocumarine: nuovi approcci terapeutici; Psoralens in cosmetics: photochemoprotection; Valutazione quantitativa di furocumarine nel materiale vegetale; Una nuova sintesi di derivati 3-alchil-4-idrossicumarinici; Two mechanisms of xanthotoxin reaction on mitotically active cells; Valutazione della qualità delle essenze agrumarie cold-pressed in relazione al contenuto in composti cumarinici e psoralenici; Coumarins and furanocumarins as trace components of beverage
Therapeutic use of levocloperastine as an antitussive agent - An overview of preclinical data and clinical trials in adults and children
No full textCough associated with acute and chronic respiratory conditions is common in patients of all ages. Levocloperastine is a novel antitussive with a pharmacological profile distinct from that of the racemic DL-cloperastine. Levocloperastine with its dual mechanism of action acts on both the central bulbar cough Centre and on peripheral receptors in the tracheobronchial tree, In preclinical studies. levocloperastine demonstrated antitussive effects similar to those observed with codeine. In acute and repeated-dose toxicity studies, levocloperastine was well tolerated in rodents and dogs, with no clinically significant cardiovascular or gastrointestinal adverse events, The pharmacokinetic behaviour of levocloperastine. best described by a two-compartmental model with absorption phase. is similar to that of the racemic compound DL-cloperastine. In clinical trials, levocloperastine had a faster onset of action and produced greater reductions in the intensity and frequency of cough compared with DL-cloperastine, codeine and levodropropizine. The antitussive effects (reduction in intensity and frequency of cough) of levocloperastine were observed after the first day of treatment in patients of all ages. In children, levocloperastine reduced night-time awakenings and irritability; in adults, it was also effective in treating ACE-inhibitor cough. Levocloperastine was generally well tolerated. There was no evidence of clinically significant central adverse events, whereas drowsiness, dry mouth and nausea were reported with comparator agents (levodropropizine, codeine, DL-cloperastine). Levocloperastine represents an effective alternative to currently used antitussive agents with the added advantage of faster onset of action and improved tolerability in all patient groups
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Hypothalamic-pituitary-adrenal axis dysregulation in healthy subjects undergoing mud-bath applications.
No full textI.F.: 7.42
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
INFLUENCE OF GLYCINE ON MORPHINE-INDUCED ANTINOCICEPTION IN MICE
No full textThe effects of glycine on morphine-induced antinociception were investigated in mice, using a cutaneous thermal test (hot-plate), a visceral chemical test (acetylcholine writhing test), and a locomotor activity test. When glycine (200 mg/kg p.o.) and morphine (5 mg/kg s.c.) were given together during the first 30 min, glycine first antagonized the morphine-induced antinociception then this was followed by a synergistic effect. The two-phase influence of glycine on morphine-induced antinociception may be due to the interaction of glycine with different receptors
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