1,721,006 research outputs found
Characteristics and prognosis of patients with acute myocardial infarction in the absence of obstructive coronary artery disease (MINOCA)
Full text linkL'infarto miocardico in assenza di coronaropatia ostruttiva (MINOCA) è definito dall'evidenza di infarto miocardico acuto spontaneo e dalla documentazione angiografica di stenosi coronariche <50%. Negli ultimi anni, sono stati fatti grandi progressi nei campi dell'epidemiologia, patofisiologia, diagnosi, stima della prognosi e terapia di questa condizione. Finora, tuttavia, la definizione di MINOCA è piuttosto eterogenea in quanto condizioni specifiche come la miocardite e la sindrome di Takotsubo sono state spesso incluse, generando così risultati contrastanti. Questa tesi di dottorato si articola in quattro parti: parte I, Introduzione; parte II, Caratteristiche e prognosi; parte III, MINOCA e morte cardiaca improvvisa; parte IV, MINOCA e terapia farmacologica. Lo scopo di questo lavoro è di valutare alcuni degli aspetti più controversi relativi a questa condizione, in particolare per quanto riguarda la prognosi e la terapia farmacologica per i pazienti affetti da MINOCA.Myocardial infarction and non-obstructed coronary arteries (MINOCA) is defined by the evidence of a spontaneous acute myocardial infarction and angiographic documentation of coronary stenosis <50% in any potential infarct related artery, after having excluded clinically overt causes for the acute presentation. The introduction of this new concept was meant to fill a gap in knowledge and to encourage discovery of putative pathophysiological mechanisms. In recent years, great advances have been made in the fields of epidemiology, pathophysiology, diagnosis, prognosis estimation and therapeutics of this condition. So far, however, the definition of MINOCA is rather heterogeneous as specific cardiac conditions such as myocarditis and Takotsubo syndrome are included thus generating conflicting results.
This doctoral dissertation is divided in four sections: part I, Introduction; part II, Characteristics and Prognosis; part III, MINOCA and Sudden Cardiac Death; part IV, MINOCA and Pharmacological Therapy.
The aim of this work is to assess some controversial aspect of this condition, in particular with regards to the prognosis and pharmacological therapy for patients affected by MINOCA
To the Editor— Flecainide and propafenone: Good twins for premature ventricular contractions’ killing but not exactly superimposable
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dissezione coronarica spontanea trattata mediante procedura coronarica percutanea eco-guidata: Descrizione di un caso clinico e revisione della letteratura
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Prediction of Outcome in Embolic Strokes of Undetermined Source
No full textBACKGROUND AND AIM: Predicting outcome after stroke is a major goal and research field. The Embolic Stroke of Undetermined Source (ESUS) is a recently introduced clinical construct, and the prediction of outcome in this population has to be further explored. The aim of the study was to evaluate the prognostic validity and accuracy of the Acute Stroke Registry and Analysis of Lausanne (ASTRAL) score in patients with ESUS. METHODS: Consecutive patients hospitalized for acute ischemic stroke who met the ESUS diagnostic criteria were identified and the ASTRAL scores estimated. The study endpoint was the 3-month unfavorable outcome (modified Rankin Scale>2). Predictive performance was investigated through logistic regression analysis and discrimination and calibration tests. RESULTS: Among 202 patients with ESUS, 67 (33.2%) had unfavourable 3-month outcome. The ASTRAL score was an independent predictor of poor outcome [adjOR = 1.44, 95% confidence interval (CI) 1.30-1.60, P < .001], showed good discriminatory power (area under the receiver operating characteristic curve .913, 95% CI .871-.956) and was well calibrated (Hosmer-Lemeshow test P = .496). CONCLUSIONS: The ASTRAL score was an independent predictor of 3-month functional outcome and showed high predictive accuracy in patients with ESUS
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