1,986 research outputs found
Esperienza clinica in presidio medico avanzato (PMA), nell’emergenza sisma di L’Aquila: studio osservazionale.
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Combined spinal-epidural anestesia (CSE) with isobaric bupivacaine: How Position influences block Characteristics.
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Khosta: A Genetic and Structural Point of View of the Forgotten Virus
No full textBats are well-known to be natural reservoirs of various zoonotic coronaviruses, which have caused outbreaks of severe acute respiratory syndrome (SARS) and the COVID-19 pandemic in 2002 and 2019, respectively. In late 2020, two new Sarbecoviruses were found in Russia, isolated in Rhinolophus bats, i.e., Khosta-1 in R. ferrumequinum and Khosta-2 in R. hipposideros. The potential danger associated with these new species of Sarbecovirus is that Khosta-2 has been found to interact with the same entry receptor as SARS-CoV-2. Our multidisciplinary approach in this study demonstrates that Khosta-1 and -2 currently appear to be not dangerous with low risk of spillover, as confirmed by prevalence data and by phylogenomic reconstruction. In addition, the interaction between Khosta-1 and -2 with ACE2 appears weak, and furin cleavage sites are absent. While the possibility of a spillover event cannot be entirely excluded, it is currently highly unlikely. This research further emphasizes the importance of assessing the zoonotic potential of widely distributed batborne CoV in order to monitor changes in genomic composition of viruses and prevent spillover events (if any)
Molecular Epidemiology of HIV-1 in African Countries: A Comprehensive Overview
No full textThe human immunodeficiency virus type 1 (HIV-1) originated in non-human primates in West-central Africa and continues to be a major global public health issue, having claimed almost 33 million lives so far. In Africa, it is estimated that more than 20 million people are living with HIV/Acquired Immunodeficiency Syndrome (AIDS) and that more than 730,000 new HIV-1 infections still occur each year, likely due to low access to testing. The high genetic variability of HIV-1, due to a fast replication cycle and high mutation rate, may cause the generation of many viral variants in a single infected patient during a single day. Therefore, the active monitoring and characterization of the HIV-1 subtypes and recombinant forms circulating through African countries poses a significant challenge to more specific diagnoses, treatments, care, and intervention strategies. In this review, a concise characterization of all the subtypes and recombinant forms circulating in Africa is presented to highlight the magnitude of the HIV-1 threat among the African countries and to understand virus genetic diversity and dispersion dynamics better
Insights into avian influenza A(H5N1) events: epidemiological patterns and genetic analysis
No full textsj-docx-1-tag-10.1177_17562848221136328 – Supplemental material for Phylogenetic analysis of Prevotella copri from fecal and mucosal microbiota of IBS and IBD patients
No full textSupplemental material, sj-docx-1-tag-10.1177_17562848221136328 for Phylogenetic analysis of Prevotella copri from fecal and mucosal microbiota of IBS and IBD patients by Alessandra Lo Presti, Federica Del Chierico, Annamaria Altomare, Francesca Zorzi, Giovanni Monteleone, Lorenza Putignani, Silvia Angeletti, Michele Cicala, Michele Pier Luca Guarino and Massimo Ciccozzi in Therapeutic Advances in Gastroenterology</p
The reemergence of measles and the urgent need for uninterrupted genetic surveillance and vaccination
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