1,721,288 research outputs found
GRK2 at the control shaft of cellular metabolism
No full textG protein receptor kinase 2 (GRK2) has been for years mainly considered the negative regulator of the cardiac β adrenergic signaling. However GRK2 is a ubiquitous molecule and its kinase activity and scaffold properties brought to several investigations which have evidenced its involvement in pathophysiology of extra-cardiac diseases. Later discoveries, moreover, indicated that this molecule is also able to influence other pathways such as insulin signaling by an inhibitory role similar to what described years before on βAR signaling. The importance of this novel function is in particular related to the possibility that this molecule can regulate the cellular metabolism, modifying the ability of cells to utilize different substrates. This hypothesis has been recently investigated in animal model of Heart Failure, evidencing that upregulation of GRK2 leads to alterations of cardiac glucose metabolism in the early stages of the disease. However GRK2 shows increased level also in the early stages of others chronic disease such as Alzheimer's Disease, indicating that these findings could be possibly applied to others cellular system and supporting the emerging idea of GRK2 as master regulator of cellular metabolism. © 2012 Bentham Science Publishers
L'architettura in una città
No full textIl testo descrive il percorso progettuale di Paola Salmoni all'interno della città di Ancona. Una architetta moderna che tra pochi ha potuto sperimentare l'efficacia del progetto architettonico e urbano in un unico luogo, un contesto di riferimento su cui operare a più riprese e in un tempo prolungato. La sua ricca attività professionale si è confrontata nel corso degli anni con le esperienze di lavoro di grandi intellettuali come Ludovico Quaroni e Giovanni Astengo che, a partire da approcci differenti al progetto, hanno tutti contribuito allo sviluppo di una concezione dell'architettura e dell'urbanistica mai ripiegata su sé stessa, ma piuttosto aperta a dialogare con le diverse condizioni di realtà antro cui si inserisce
Il ruolo delle emozioni negative nei meccanismi attentivi e nell'insoddisfazione corporea
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ALESSITIMIA, RICONOSCIMENTO EMOTIVO E BIAS ATTENTIVI NELLE CONDOTTE ALIMENTARI: UNO STUDIO SU ADOLESCENTI
No full textExploring how new industrial paradigms affect the workforce: A literature review of Operator 4.0
Full text linkThe ongoing paradigm transition from Industry 4.0 to Industry 5.0 is driving toward a new industrial vision rooted in addressing human and planetary needs rather than solely focusing on innovation for profit. One of the most significant shifts that defines Industry 5.0 is the change in focus from technology-driven progress to a genuinely human-centric approach. This means that the industrial sector should prioritize human needs and interests at the core of the production process. Instead of replacing workers on the shop floor, technologies should enhance their capabilities, leading to a safer and more fulfilling work environment. Consequently, the role of industrial operators is undergoing a substantial transformation. This subject has garnered increasing interest from both researchers and industries. However, there is a lack of comprehensive literature covering the concept of Operator 4.0. To address this gap, this paper presents a systematic literature review of the role of Operator 4.0 within the manufacturing context. Out of the 1333 papers retrieved from scientific literature databases, 130 scientific papers met the inclusion criteria and underwent detailed analysis. The study aims to provide an extensive overview of Operator 4.0, analyzing the occupational risks faced by workers and the proposed solutions to support them by leveraging the key enabling technologies of Industry 4.0. The paper places particular emphasis on human aspects, which are often overlooked although the successful implementation of technologies heavily relies on who uses them and how they are utilized. Finally, the paper discusses open issues and challenges and puts forth suggestions for future research directions
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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