1,721,045 research outputs found
Italian national consensus conference on prostate cancer screening (Florence, May 17, 2003)--final consensus document.
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B3 breast lesions determined by vacuum-assisted biopsy: how to reduce the frequency of benign excision biopsies
No full textPURPOSE: The aim of this study was to identify parameters allowing differentiation among the diverse group of B3 lesion at stereotactic vacuum-assisted biopsy (VAB) to identify patients with a low risk of cancer and who can therefore be referred for follow-up rather than surgery and thus reduce the number of unnecessary surgical procedures.MATERIALS AND METHODS: Among 608 VAB procedures performed for nonpalpable ultrasound (US)-occult mammographic abnormality, 102 cases of B3 were included in this study. Mammographic lesion type, lesion size, Breast Imaging Reporting and Data System (BIRADS) category, number of specimens per lesion and presence of atypia were retrospectively analysed. Results were compared with histological findings at surgery (53 cases) or mammographic findings during follow-up (49 cases). Statistical analysis was performed with univariate analysis (chi-square test), and statistical significance was set at p<0.05.RESULTS: The majority of cases were depicted as isolated microcalcifications (82.3%), were smaller than 10 mm (80.4%), had a low level of radiological suspicion (64.7%) and had 11 or more cores sampled (94.1%). Atypia at VAB was reported in 60 of 102 cases (58.8%). Carcinoma was found at excision in 5/60 (8%) B3 lesions with atypia and in no B3 lesions without atypia (p=0.146). Cancer at surgery was more frequent among cases of isolated microcalcifications (p=0.645), cases with high radiological suspicion (p=0.040) and those with a smaller number of cores sampled (borderline significant p=0.064).CONCLUSIONS: On the basis of our experience, the presence or absence of atypia in our series proved to be the reliable criterion to prompt or avoid surgery in cases with a VAB finding of B3 lesion. This criterion may therefore be adopted in practice to more accurately select patients for surgery
Trattamento radioterapico delle recidive postchirurgiche da cancro del retto-sigma: impatto sulla qualità della vita residua e significato della dose somministrata
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Breast ultrasound in 22,131 asymptomatic women with negative mammography
No full textPurpose: To evaluate increment cancer detection rate generated by
ultrasound (US).
Materials and methods: US only detected cancers were assessed for 22,131
self-referring asymptomatic women with negative mammography and
subgroups by age, previous cancer, breast density. Invasive assessment
and surgical biopsy rate were evaluated.
Results: The overall US detection was 1.85 per thousand (41/22,131). In
the subgroups it was: 1.95 per thousand (22/11,274) in women <50 years
vs 1.75 per thousand (19/10,857) in women >= 50 years (p = 0.42), 5.49
per thousand (12/2183) in women with previous cancer vs 1.45 per
thousand (29/19,948) in women without cancer history (p = 0.0004), 2.21
per thousand (22/9960) in dense breasts (p = 0.17) vs 1.56 per thousand
(19/12,171) in fatty breasts. The US generated invasive assessment was
1.9\% (422/22,131). The benign to malignant open surgical biopsy ratio
was 0.17 (7/41).
Conclusion: Adding US to negative mammography allowed for substantial
incremental cancer detection rate (1.85 per thousand), particularly at
age <50years, in women with previous breast cancer and in dense breasts.
(C) 2013 Elsevier Ltd. All rights reserved
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