1,721,225 research outputs found
Les Orchidées
No full textCianfarani S. Les Orchidées. In: Bulletin mensuel de la Société linnéenne de Lyon, 44ᵉ année, n°10, décembre 1975. pp. 42-45
Risk of cancer in patients treated with recombinant human growth hormone in childhood
No full textRecombinant human growth hormone (GH) has been in use for over 30 years, and its indications have gradually expanded from the classical replacement therapy in GH deficiency (GHD) to pharmacological therapy in patients with normal GH secretion. The insulin-like growth factor-I (IGF-I) is closely GH dependent and is the effector of GH biological actions in peripheral tissues. Since IGF-I has potent mitogenic and antiapoptotic effects, the use of GH, especially outside GHD, has raised safety concern regarding cancer risk. The results of experimental, epidemiological and observational studies are not univocal and a number of biases and confounders affect the interpretation of data. The aim of this review is to critically review the data linking GH therapy during childhood with cancer risk, highlighting strengths and weaknesses of the available evidence
Retraction: Effects of Vitamin D Supplementation on Calcium Balance and Bone Growth in Young Rats Fed Normal or Low Calcium Diet(Fetal Diagnosis and Therapy (2004) 61 (293?299) DOI: 10.1159/000077346)
No full textRetraction: Effects of Vitamin K2 Administrationon Calcium Balance and Bone Mass in Young Rats Fed Normal or Low Calcium (Fetal Diagnosis and Therapy (2005) 63:5 (211?219) DOI: 10.1159/000085681)
No full text
Safety of Pediatric rhGH Therapy: An Overview and the Need for Long-Term Surveillance
Full text linkGrowth hormone (GH) therapy dates back to 1958 and, though has shown an excellent safety profile in the short-term, has never ceased to raise concern about potential long-term side effects. In the last decade, a number of observational studies in different cohorts of young adult patients treated with GH during childhood have yielded conflicting results. The attention has mainly focused on three major potential risks associated with GH therapy: cancer, cardio and cerebrovascular diseases and diabetes. This review intends to provide a detailed overview of the main studies reporting long-term safety in subjects treated with rhGH therapy during childhood, highlighting the evidence for or against the risk of cancer, cardio and cerebrovascular diseases and diabetes
Bambini Nati Piccoli per Età Gestazionale (small for gestational age, SGA): Implicazioni Cliniche. Come, Quando e Perchè Trattarli con l’Ormone della Crescita
No full textPrecocious puberty [La pubertà precoce]
No full textPrecocious puberty is a condition that has both physical and psychological effects on affected children and their families. Therefore, an accurate work up is necessary to understand the dynamic course of the disease in terms of rate of pubertal progression, statural growth, bone age progression, development of reproductive functions and psychosocial adjustment and wellbeing. The salient clinical, laboratory and radiological features of the possible causes of precocious puberty are reviewed and the current therapeutic options are discussed
- …
