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    Ideas for a phenomenological interpretation and elaboration of personal construct theory. Part 1. Kelly between constructivism and phenomenology

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    Kelly’s personal construct theory, put forward in 1955, is considered the first constructivist theory of personality and the first expression of those contemporary psychotherapeutic perspectives grounded on a constructivist view of knowledge. Notwithstanding the similarities between psychological constructivism and the phenomenological-hermeneutic tradition, Kelly always rejected the parallel of his theory to phenomenology, regarding the latter as unacceptable since idealistic, solipsistic, and particularistic. In this first article of a work subdivided into three parts, the Authors explain such criticism by Kelly with his knowledge of phenomenology deriving from secondary sources, and stress the wide possibilities of a phenomenological interpretation and elaboration of his theory

    Ideas for a phenomenological interpretation and elaboration of personal construct theory Part 2. Husserl and Kelly: A case of commonality

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    In the first part of their work, the Authors substantiated the strong similarities between Kelly’s personal construct theory and phenomenology, notwithstanding the rejection of the latter from the American psychologist. In this second article the Authors go so far as to uphold the thesis that Kellyan theory even represents an example of the realization of the Husserlian project of a rigorous science of experience, alternative to the naturalistic one. After having briefly expounded the new idea of objectivity described by Husserl, Kelly’s theory is presented as world of the general forms deriving from experience, which take shape as structural invariants in Kelly’s enunciation of professional constructs

    Multi-scale modeling of Snail-mediated response to hypoxia in tumor progression

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    Tumor cell migration within the microenvironment is a crucial aspect for cancer progression and, in this context, hypoxia has a significant role. An inadequate oxygen supply acts as an environmental stressor inducing migratory bias and phenotypic changes. In this paper, we propose a novel multi-scale mathematical model to analyze the pivotal role of Snail protein expression in the cellular responses to hypoxia. Starting from the description of single-cell dynamics driven by the Snail protein, we construct the corresponding kinetic transport equation that describes the evolution of the cell distribution. Subsequently, we employ proper scaling arguments to formally derive the equations for the statistical moments of the cell distribution, which govern the macroscopic tumor dynamics. Numerical simulations of the model are performed in various scenarios with biological relevance to provide insights into the role of the multiple tactic terms, the impact of Snail expression on cell proliferation, and the emergence of hypoxia-induced migration patterns. Moreover, quantitative comparisons with experimental data show the model's reliability in measuring the impact of Snail transcription on cell migratory potential. Through our findings, we shed light on the potential of our mathematical framework in advancing the understanding of the biological mechanisms driving tumor progression
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