1,720,989 research outputs found
New perspectives in pediatric dialysis technologies: the case for neonates and infants with acute kidney injury
Full text linkAdvancements in pediatric dialysis generally rely on adaptation of technology originally developed for adults. However, in the last decade, particular attention has been paid to neonatal extracorporeal therapies for acute kidney care, an area in which technology has made giant strides in recent years. Peritoneal dialysis (PD) is the kidney replacement therapy (KRT) of choice in the youngest age group because of its simplicity and effectiveness. However, extracorporeal blood purification provides more rapid clearance of solutes and faster fluid removal. Hemodialysis (HD) and continuous KRT (CKRT) are thus the most used dialysis modalities for pediatric acute kidney injury (AKI) in developed countries. The utilization of extracorporeal dialysis for small children is associated with a series of clinical and technical challenges which have discouraged the use of CKRT in this population. The revolution in the management of AKI in newborns has started recently with the development of new CKRT machines for small infants. These new devices have a small extracorporeal volume that potentially prevents the use of blood to prime lines and dialyzer, allow a better volume control and the use of small-sized catheter without compromising the blood flow amount. Thanks to the development of new dedicated devices, we are currently dealing with a true “scientific revolution” in the management of neonates and infants who require an acute kidney support
Technicalities, current evidence, and clinical indications of hemoadsorption in critically ill children
No full textHemoadsorption devices represent a significant advancement in extracorporeal organ support therapies, enabling the targeted removal of molecules that are not cleared by conventional kidney replacement therapies. Several hemoadsorption devices are currently available, each with distinct characteristics, mechanisms of action, and molecular adsorption profiles that enable their targeted use in a broad range of clinical scenarios in critically ill patients. Their application has recently been explored in pediatric patients with conditions such as septic shock, acute liver failure, hyperinflammatory syndromes, rhabdomyolysis, and intoxications. Preliminary findings suggest both clinical and biochemical improvements, including reduction in severity scores and circulating inflammatory mediators. However, the current body of evidence remains limited, primarily consisting of case reports and small case series, and often lacks robust clinical trial data. In the pediatric population, several challenges persist, including concerns about device sizing, the unintended removal of essential substances, such as medications, nutrients, albumin, and fibrinogen, and the procedural invasiveness, particularly for younger children. Future research should focus on patient stratification to identify those most likely to benefit from hemoadsorption, and on conducting large, multicenter studies to validate its effectiveness and utility in the pediatric setting
Expanding the Spectrum of Extracorporeal Strategies in Small Infants with Hyperammonemia
No full textHyperammonemia is a life-threatening condition mainly due to the neurotoxicity of ammonia. Ammonia scavengers may be insufficient, and extracorporeal treatment may be required. Continuous treatments are preferred, and a high-dose continuous renal replacement therapy (CRRT) must be prescribed to ensure a fast ammonia depletion. Many of the children with hyperammonemia are newborns, with lower blood volume than older children. The majority of the CRRT systems are adult-based, with large extracorporeal priming volumes and inadequate UF control. Recent strides have been made in the development of CRRT systems more suitable for young children with smaller sets to use in adult machines and dedicated monitors for neonates and infants. The main advantage of the machines for adults is the higher dialysis fluid flows, however with greater hemodynamic risks. Pediatric monitors have been designed to reduce the extracorporeal volume and to increase the precision of the treatment. However, they have substantial limitation in clearance performances. In this review, we discuss on current strategies to provide CRRT in newborns and small infants with hyperammonemia. We also presented our experience with the use of CARPEDIEMTM implemented in a CVVHDF modality, boosting the diffusive clearance with a post-replacement convective mechanism
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Parasitic infections of Chamelea gallina (Mollusca, Bivalvia) from commercially exploited banks of the Adriatic Sea
No full textA parasitological survey of the bivalve Chamelea gallina was carried out from natural beds of the Adriatic Sea, where anomalous mortalities were observed during the last years (1997-1999). The occurrence of protozoans belonging to the families Porosporidae, Hemispeiridae and Trichodinidae was recorded. Porosporidae of the genus Nematopsis, present with 4 species, showed a prevalence of 100%, irrespective of sampling localities, season or bivalve size, but differences were found when percentage of infection was calculated per organ. As for the genus Porospora this is the first record in C. gallina. Among Hemispeiridae, the genera Ancistrum and Boveria were found in the gills. The results suggest that severe infections of protozoans of the genus Nematopsis could cause a not negligible respiratory sufferance, with a possible role in the decline of the natural banks
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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