1,720,971 research outputs found
Symmetric sensorineural progressive hearing loss from chronic idiopathic pachymeningitis
No full textWe present the case of a 68 year-old man with a diffused hypertrophic pachymeningitis (HP) involving both internal auditory canals. The clinical symptoms were headache, decreased vision in one eye, progressive bilateral and symmetrical sensory-neural hearing loss (PSNHL) responsive to steroid treatment. Although hearing loss is a frequent manifestation of HP, only few studies reported an adequate audiological assessment and follow-up. Mechanisms related to the auditory involvement are discussed on the basis of audiological data. Gadolinium enhanced MRI is the most adequate technique for HP detection and for the differential diagnosis. A delay in the diagnosis of HP seems to be quite common and the consequences may be severe, especially in cases of optic nerve involvement. For these reasons, a cerebral MRI should probably be included in the assessment of PSNHL, especially when neurological signs coexist or are reported in the medical history
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
La misurazione continua della Pressione Intracranica (PIC) come indice della valutazione dello spasmo arterioso post-emorragico.
No full textStudio delle modificazioni della PIC in rapporto allo spasmo arterioso post-emorragic
TC e monitoraggio della PIC nell'idrocefalo non tumorale dell'adulto: significato della TC
No full textValutazione dell'immagine TC in relazione ai vari quadri di idrocefalo non tumorale dell'adult
The diagnosis and clinical management of the neuropsychiatric manifestations of lupus
No full textNeuropsychiatric (NP) involvement in Systemic Lupus Erythematosus (SLE), can be a severe and troubling manifestation of the disease that heavily impacts patient's health, quality of life and disease outcome. It is one of the most complex expressions of SLE which can affect central, peripheral and autonomous nervous system. Complex interrelated pathogenetic mechanisms, including genetic factors, vasculopathy, vascular occlusion, neuroendocrine-immune imbalance, tissue and neuronal damage mediated by autoantibodies, inflammatory mediators, blood brain barrier dysfunction and direct neuronal cell death can be all involved. About NPSLE a number of issues are still matter of debate: from classification and burden of NPSLE to attribution and diagnosis. The role of neuroimaging and new methods of investigation still remain pivotal and rapidly evolving as well as is the increasing knowledge in the pathogenesis. Overall, two main pathogenetic pathways have been recognized yielding different clinical phenotypes: a predominant ischemic-vascular one involving large and small blood vessels, mediated by aPL, immune complexes and leuko-agglutination which it is manifested with more frequent focal NP clinical pictures and a predominantly inflammatory-neurotoxic one mediated by complement activation, increased permeability of the BBB, intrathecal migration of autoantibodies, local production of immune complexes and pro-inflammatory cytokines and other inflammatory mediators usually appearing as diffuse NP manifestations. In the attempt to depict a journey throughout NPSLE from diagnosis to a reasoned therapeutic approach, classification, epidemiology, attribution, risk factors, diagnostic challenges, neuroimaging techniques and pathogenesis will be considered in this narrative review based on the most relevant and recent published data
Supratentorial cavernous angiomas and epilepsy: Which treatment?
No full textCavernous angiomas (CAs) are cerebrovascular malformations most commonly found in investigations of new onset epilepsy. While previously felt to be rare, widespread use of magnetic resonance imaging (MRI) studies reveals a surprisingly high incidence of these lesions, suggesting that CAs may be a frequent cause of epilepsy in the past considered to be of cryptogenic origin. The natural history of CAs is presently poorly understood. The pathogenic potential of these anomalies is still controversial as well as optimal therapeutic strategies for their management. Twelve cases (7 males and 5 females, aged 26-65 years) entered the study upon MRI documentation of supratentorial CAs, neurological examination and EECI. Four have undergone ablative surgery consisting of lesion removal ("lesionectomy") or a larger corticectomy. Of H patients under pharmacological treatment alone, 4 have been seizure-free (for a period ranging from 6 months to 3 years). In contrast, of the 4 surgical patients 2 have been seizure-free, and 2 have undergone a reduction in the frequency and/or severity of epileptic episodes. Therefore, in line with other reports indicating a low incidence of spontaneous bleeding of CAs, the present study suggests that surgery is not always recommended unless there has been a significant clinical hemorrhage and epilepsy can often be successfully managed with anti-epileptic pharmacological treatment. Moreover, the likelihood of relapse of epilepsy in patients who undergo surgical ablation seems to depend mostly upon the frequency, duration of preoperative seizure history and severity of seizures prior to surgery. Thus, surgery for CAs should probably be used only after intensive early evaluation for drug responsiveness in patients who appear unlikely to be adequately managed medically
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