1,721,031 research outputs found
ELDERLY PATIENTS WITH ADVANCED COLORECTAL CANCER: TOLERABILITY AND ACTIVITY OF CHEMOTHERAPY
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Symptomatic effects of methotrexate, 5fluorouracil and leucovorin in advanced colorectal cancer after failure of 5FU continuous infusion
No full textTwenty-two advanced colorectal cancer patients, refractory to 5FU CI, were given methotrexate 200 mg/m(2) as a 30 minutes i.v. infusion, followed 24 hours later by 5FU at the dose of 600 mg/m(2) as a 15 minutes i.v. infusion, and leucovorin 10 mg/m(2) orally every 6 hours for 6 times. The cycle was repeated every 2 weeks. There were two partial responses (9%; 95% CI 6%-12%), while eleven patients achieved a stabilization of disease. Toxicity was extremely mild. Symptoms relief occurred in 26/41 cases (63%), Median duration of palliation was 11 weeks (range 4-18), Our results confirm that biochemical modulation with MTX is not a satisfactory mean of increasing 5FU activity in patients previously exposed to 5FU CI, However, the significant symptom palliation appears highly worthwhile, and it could be considered in the decision to treat symptomatic colorectal cancer patients refractory to 5FU CI
[Haemolytic anaemia associated with acquired deficiency of erythrocyte glutathione peroxidase: use of sodium selenite to correct the enzyme defect (author's transl)]
No full textQuantitative MR imaging data in the evaluation of hepatic metastases during systemic chemotherapy
No full text[Adrenal metastasis: clinical and pathological aspects].
No full textThe clinical and autopsy records of 91 patients who died of various malignancies in January 1980-December 1985 were reviewed with regards to metastatic involvement of the adrenal glands. Metastatic involvement was found in 28/91 i.e. 30.7% of all cases, and in 17/30 cases of lung cancer (56.6%). Although in the majority of cases adrenal metastases were associated with widespread metastatic (terminal) disease, thus questioning the utility of clinical surveillance, in 4/17 cases with lung cancer the adrenals were the only visceral site of metastasis. Symptoms were rarely seen and were in all instances aspecific and attributable to the underlying cancer. Early and accurate identification of suprarenal metastasis would, at least in these cases, be a great help in deciding on the therapeutic approach. Unfortunately our ability to diagnose these metastases is somewhat limited partly because the symptoms are few and aspecific, partly because we lack efficient and economical diagnostic techniques. In fact the simpler laboratory techniques cannot identify early metastatic lesions. However assessment of the adrenals should be part of routine staging and restaging procedures in some neoplasias, for the frequency and clinical relevance of these lesions
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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