1,721,091 research outputs found
) Maggio M, Manganelli P, Ceda GP, Denti L, Rebecchi I, Ablondi F, VALENTI G Diminuzione età e sesso correlata della secrezione di DHEAS in pazienti con patologie infiammatorie croniche trattate con corticosteroidi
No full textGIORNATE ITALIANE DI ENDOCRINOLOGIA GERIATRIC
Prolactin response to TRH after intravenous cimetidine.
No full textCimetidine administered intravenously to six healthy volunteers caused a significant increase in plasma prolactin response to TRH. The meaning of these results and their relation with the physiological role of histamine H2-receptors in the control of prolactin secretion is discussed
Proceedings of the Meeting on Geriatric Endocrinology devoted to the issue of "Aging Male".
No full textCeda GP, Vargas N, Magnacavallo A, Maggio M, Fontana V, Banchini A, Lena L, Valenti G. Dose-response study with transdermal estradiol on the GH-IGF axis of elderly women.
No full textThe relationship between testosterone levels and muscle mass and strength over the lifespan in men.
No full text
Approaching Neurological Diseases to Reduce Mobility Limitations in Older Persons
No full textAbstract
The rapidly increasing elderly population poses a major challenge for future health-care systems. Neurological diseases in older persons are particularly common and coexist with other clinical conditions. This is not surprising given that, for example, even patients with Alzheimer Disease (AD) could have relevant extrapyramidal signs at the moment of the diagnosis with motor signs having more negative prognostic value. Longitudinal studies conducted on Parkinson Disease (PD) showed that, after 20 years, dementia is not only present in almost all survivors but is also the main factor influencing nursing home admission. Recently, it has been reported the importance of Comprehensive Geriatric Assessment (CGA: comprehensive evaluation of cognition, depressive symptoms, mobility and functional assessment) as a tool reducing morbidity in frail older patients admitted to any acute hospital unit. The CGA should be considered as a technological device, for physicians who take care of older persons affected by overlapping neurological diseases. CGA is an extraordinary and cost effective instrument even in patients with advanced neurological diseases where allows to collect valuable information for an effective plan of management
Omega-3 and renal function in older adults.
No full textChronic kidney disease (CKD) is a major public health problem and can result in end-stage renal disease with need for dialysis or transplantation. In Europe up to 12% of the adult population had some renal impairment, while in the United States the end stage of CKD has increased dramatically from 209.000 in 1991 to 472.000 in 2004. Diabetes and hypertension are major causes of kidney pathology. Infection, particularly ascending infection, is more common with increasing age, as both immune function declines and associated pathology predisposing to infection, such as obstructive uropathy, becomes more common. Most pathological changes in the kidney appear to be initiated by oxidative stress, followed by an inflammatory reaction. Oxidative stress results from an imbalance between free radicals and their detoxification by endogenous and exogenous scavengers, including polyunsaturated fatty acids (PUFA). Recent studies showed that PUFA supplementation slowed the rate of loss of renal function in patients with IgA nephropathy. Then, studies of omega-3 supplementation in dialysis patients describe salutary effects on triglyceride levels and dialysis access patency. We examined the relationship between total plasma PUFA levels and change in creatinine clearance over a three-year follow-up in the older persons enrolled in the InCHIANTI study, a population-based epidemiology study conducted in Tuscany, Italy. This study showed that older adults with low total plasma PUFA levels have a greater decline in creatinine clearance over three years of follow-up. These findings suggest that a higher dietary intake of PUFA may be protective against progression to chronic kidney disease
Testosterone and interleukin-6-soluble rceptor: endocrine and immune systems interplay in older men
No full textTHE GERONTOLOGIS
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