1,721,099 research outputs found
Loffredo V., Torromino G., Esposito F., Carboncino A., Cecere A., Mele A., De Leonibus E. "Sex regulates memory capacity"
No full textMemory Capacity (MC) is the number of information maintained in memory. MC is regulated by fronto-striatal dopamine circuit and hippocampus (HP).
Using a modified version of the object recognition task, the DOT/IOT, we have recently showed that adult naïve male mice could discriminate 3,4,6 but not 9 different objects after a 1 min or 24 hrs delay. Moreover, it has been reported that male mice use the HP, as well as humans, to solve the task (Sannino et al 2012, Olivito et al 2014; Sugita et al 2015).
To report sex differences influencing MC, we have challenged 3 months old mice (males and females) with the 6-DOT (highest memory load), testing them at different time points.
We have found that 3 months old female mice properly perform the 6-DOT when tested at 1 min delay (Short Term Memory, STM), but they are impaired when tested 24 hr later (Long Term Memory, LTM). Female mice properly perform the 6-IOT (lowest memory load) independently on the delay.
We hypothesized that the impairment in LTM could reflect sex regulated differences in the use of different neuronal circuits to solve the task. Therefore, we are performing c-fos immunohistochemical analysis as an index of stimuli-induced neuronal activation on the HP and the prefrontal cortex, at different time points after exposing the animals to the 6-DOT. Preliminary data show that female mice, differently from males, do not activate the HP.
Sex-regulated neuronal activation might be relevant to understand the higher impact of dementia in women as compared to men
TIDE: a computer program of refinement of the Chapman-Miller method for the determination of lunar tides
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TIDE: a computer program of refinement of the Chapman-Miller method for the determination of lunar tides
No full textLetter to the Editor: "GLP-1 Receptor Agonist Treatment Increases Bone Formation and Prevents Bone Loss in Weight-Reduced Obese Women" by Iepsen E.W., et al.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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