217 research outputs found
CD20-Mimotope Peptides: A Model to Define the Molecular Basis of Epitope Spreading
No full textAntigen-mimicking peptide (mimotope)-based vaccines are one of the most promising forms of active-immunotherapy. The main drawback of this approach is that it induces antibodies that react poorly with the nominal antigen. The aim of this study was to investigate the molecular basis underlying the weak antibody response induced against the naïve protein after peptide vaccination. For this purpose, we analyzed the fine specificity of monoclonal antibodies (mAb) elicited with a 13-mer linear peptide, complementary to theantigen-combining site of the anti-CD20 mAb, Rituximab, in BALB/c mice. Anti-peptide mAb competed with Rituximab for peptide binding. Even so, they recognized a different antigenic motif from the one recognized by Rituximab. This explains their lack of reactivity with membrane (naïve) CD20. These data indicate that even on a short peptide the immunogenic and antigenic motifs may be different. These findings highlight an additional mechanism for epitope spreading and should be taken into account when designing peptides for vaccine purposes
La riforma (ancora in cantiere) della magistratura onoraria e la decisione della Consulta n. 41/2021: la partecipazione degli ausiliari nei collegi d’appello “sarà” costituzionalmente illegittima
No full textTaking into account the outcomes of the sentence no. 41/2021 of Italian Constitutional Court, which declared the incostincency of the legislation that introduced the “auxiliary judges” in the appeal
courts, the Author reflects on the current role of the non professional judges, in a general context of law-making’s and case-law’s interest on the subject. The Author analyzes also the decision-making process adopted by the Court which led to the “manipulation” of the temporal effects of the decision upholding the question of constitutional inconsistency
Centro Studi di Preistoria e Archeologia di Sorgenti della Nova. I materiali del Bronzo Finale
No full textMarsico G., Valsiner J. (2018). Is there any reason for suffering—for science in psychology? In G. Marsico & J. Valsiner, J. (2018). Beyond the Mind: Cultural Dynamics of the Psyche. (pp. 49-52), Charlotte, N.C. USA: Information Age Publishing;
No full textPart I includes texts about the current state of affairs in psychology, and of the emergence of the new area—cultural psychology—that turns out to be older than psychology itself. The sentiments expressed in these two papers seem to represent the doubts their author has about the future of psychology as a science
Spunti per il dibattito sul Regolamento (UE) 2017/625: armonizzazione normativa e atti delegati
No full textIn this work the Author examines the legislative technique used by the European Parliament in the regulation 625 of 2017 which entrusts the instrument of delegation with the integration of important parts of the same and highlights how this technique removes the European legislator from the aim pursued rationalization and simplification of the global regulatory framework by integrating the rules relating to official controls, currently located in specific sectors, in a single regulatory framework relating to official controls
Il Messale di Gjon Buzuku: la lingua materna nella prassi liturgica albanese
No full textMeshari ‘The Missal’ (1555) is the first known printed book in Albanian. It is a translation from the Latin of the Catholic Missal, made by the ecclesiastical Gjon Buzuku. The only known copy extant is preserved in the Apostolic Library of the Vatican in Rome. It is missing the frontispiece and the first 16 pages, so the title and place of publication of the work are not known. The place the book was printed is thought to be Venice. The Meshari contains texts of prayers, rituals, catechetical texts and the liturgies of the main holidays. All we know about the author is from the book’s colophon written by Buzuku himself in Albanian. In the colophon, he explains the reasons that led him to divulge the Christian doctrine using the language of its land. The time in which The Meshari appeared was of great cultural decay for Albania, a land where frictions have been consumed between Catholicism and Orthodoxy, and where Christian and Muslim civilizations were one against the other. Buzuku offers to the people of Albanian believers to approach the Sacred scriptures through their language. Since the use of Latin was far from the understanding of Albanian people, Buzuku translated the divine Word in order to allow that it was comprehensible to the Albanian Christians
Andrej Belyj. Sinfonia (2-a, la drammatica). E il tempo scorreva senza sosta...
No full textAndrej Belyj (1913-1914), esordisce nel 1902 con un’opera che inaugura in Russia il genere letterario della sinfonia. Nell’introduzione a Sinfonia (2-a, la drammatica) Belyj spiega che l’opera «ha tre significati: uno musicale, uno satirico e uno ideologico-simbolico». Dal «significato musicale», che porta l’autore a «dividere la sinfonia in parti, le parti in frammenti e i frammenti in versi (frasi musicali)», nasce il genere misto di prosa e poesia di cui Belyj si serve per enfatizzare il contenuto mistico, satirico e grottesco dell’opera, che caratterizzerà poi anche Pietroburgo. Nella Seconda sinfonia}Belyj prende di mira i gruppi di mistici che andavano formandosi all’inizio del Novecento a Mosca e Pietroburgo, citando esplicitamente o raffigurando velatamente personaggi reali del mondo della letteratura, dell’arte e della filosofia, come Vladimir Solov’ev (1853-1900), Dmitrij Merežkovskij (1865-1941) e altri. Motivi strettamente autobiografici vengono così presentati sotto forma di immagini grottesche e iperboliche, alternate a momenti di estremo lirismo. Al «significato musicale» è legata anche la particolare scansione del tempo in cui si dispiega la trama dell’opera, che inizia con il lento trascorrere di un’intera giornata e accelera poi nel passare dei mesi e delle stagioni per ritornare, ciclicamente e drammaticamente, al punto di partenza. Questo procedimento artistico è ben sintetizzato in uno dei leitmotive dell’opera: «E il tempo scorreva senza sosta, e nello scorrere del tempo si rifletteva l’Eternità brumosa». Andrei Bely (1880-1934), poet, novelist, theorist and literary critic of the Russian Symbolist movement, author of the famous novel in rhythmic prose Petersburg (1913-1914), made his literary debut in 1902 with a work introducing in Russia a new literary genre, the symphony. In the introduction to The Dramatic Symphony, Bely explains that the work «has three meanings: a musical meaning, a satirical meaning, and a symbolic ideological meaning». The «musical meaning» inspires the author in splitting the Symphony «into parts, the parts into fragments, and the fragments into verses (musical phrases)», thus creating a new literary genre, which combines prose and poetry, and emphasizes the mystic, satirical and grotesque content of the work. This mix of prose and poetry is also typical of the novel Petersburg. In the Dramatic Symphony Bely was targeting groups of mystics operating in the early 1900’s in Moscow and Saint Petersburg. He openly mentions or covertly alludes to actual protagonists of the literary, artistic and philosophical Russian society: Vladimir Solovyov (1853-1900), Dmitry Merezhkovsky (1865-1941) and others. Strictly autobiographical themes are presented in form of grotesque and hyperbolic images, alternating with moments of great lyrical tension. The «musical meaning» is also linked to the particular conception of time through which the plot of Bely’s Symphony is developed. At the beginning, a whole day passes by very slowly; then time speeds up and the plot goes through several months and seasons. At the end of the work we are back to where we started, like in a dramatic cycle. This method is well summarized in one of the leitmotive of the work: «And the time flowed without stopping, and the passage of time reflected the Eternity misty».</p
Marsico, G., Brandelli Costa, A., (2023). The Journal’s Growth: The Role of the Associate Editors, Trends in Psychology. 10.1007/s43076-023-00296-6
No full textIt is always with great happiness that we announce the growth of our journal. Based
on Springer annual report, since 2020, the journal has doubled the number of articles
accepted for publication. Also, the number of accesses to the full texts of published
articles increased by almost three times. The journal has also seen an increasing
diversity in terms of geographic regions for both the submissions received and
the accesses, with author and readers from all the continents. This is the result of the
collective efforts of our associate editors, along with the Brazilian Society of Psychology and the Springer Team
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