1,721,033 research outputs found
Potential of photodynamic therapy in the management of infectious oral diseases
Full text linkIn recent years there are more and more multi-drug resistant infections also at the oral level and this has led researchers to find alternative solutions to conventional pharmacology that have no impact on systemic health. Among these is photodynamic therapy, which has demonstrated efficacy both in vitro and in vivo, both in bacterial, viral (reducing recrudescence) and fungal infections, in particular Candida spp multidrug resistant
FOTODINAMICA CON PEROSSIDO D’IDROGENO ATTIVATO DA DIODO A LUCE BLU NEL TRATTAMENTO DELLA MALATTIA PARODONTALE E PERIMPLANTARE
No full textTitolo Abstract FOTODINAMICA CON PEROSSIDO D’IDROGENO ATTIVATO DA DIODO A LUCE
BLU NEL TRATTAMENTO DELLA MALATTIA PARODONTALE E
PERIMPLANTARE
Scopo: Valutare l'efficacia della terapia fotodinamica (PDT) con perossido d’idrogeno
(H2o2) al 3% associata alla terapia parodontale non chirurgica (SRP) come
approccio non antibiotico al trattamento della malattia parodonto/implantare.
Materiali e metodi: Pazienti con parodontite e perimplantite sono stati divisi in 4 gruppi. In 2 gruppi
sperimentali, 8 tasche parodontali e 8 perimplantari sono state trattate con SRP e
PDT, 2 gruppi controllo hanno ricevuto solo SRP. Al t0 sono stati registrati gli indici
parodontali/perimplantari, eseguito SRP ed istruzione igiene orale con spazzolino
elettrico roto-oscillante e scovolino in gomma. Sono stati poi divisi 2 gruppi
implantari/parodontali trattati con PDT e 2 gruppi di controllo trattati con SRP. La
fotodinamica è stata eseguita con perossido d’idrogeno al 3% inserito nella tasca e
attivato per 2 minuti con un diodo a luce blu di lunghezza d’onda compresa tra 420
a 480 nm. A 2 e a 7 giorni, t1 e t2, è stata ripetuta PDT. I gruppi controllo al t1 e t2
hanno ricevuto SRP.
Risultati: La profondità al sondaggio media nel campione con perimplantite trattata con PDT e
nel gruppo controllo al t0 era di 4 mm. Tale valore al tempo t3, a 6 settimane,
risultava nel primo gruppo 2 mm e nel gruppo controllo 3 mm. La riduzione era del
25% nel gruppo controllo e del 50% nel gruppo sperimentale. Il valore di placca
risultava essere al t0 del 91% e del 94% nel gruppo controllo. La riduzione di placca
era di 72,5% nel gruppo sperimentale e del 46,8% nel gruppo controllo. Il
sanguinamento nel gruppo sperimentale era di 83% e nel gruppo controllo del
77,5%. La riduzione era del 100% nel gruppo sperimentale e del 35,4% nel gruppo
controllo. Tutte le differenze risultano statisticamente significative per p 0,05. Nel
gruppo parodontiti i risultati ottenuti non era statisticamente significativi per p 0,05.
Conclusioni: L’associazione SRP e PDT con H2o2 al 3% è risultata efficace nel trattamento
mininvasivo delle perimplantiti. Ulteriori studi saranno necessari per confermare
questo risultato
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Epigenetic mechanisms in oral cancer: new diagnostic and therapeutic strategies
Full text linkComplexity and heterogeneity are frequently present during the development and progression of carcinogenesis and, in the last 15 years, significant progress made in clinical research underlines the role of
some epigenetic mechanisms. The most important characteristics of the epigenetic concept are that these
events are reversible, not related to modifications in the structure of DNA and may drive fundamental cell
signaling alterations1. Among these systems of communication in normal and pathological conditions,
also microbiome and staminal cells2 seem to be important. These new profiles of pathological communication develop novel diagnostic, prognostic and therapeutic tool
CORRELATION BETWEEN ORAL HYGIENE AND HEART HEALTH: AWARENESS AND INNOVATIVE STRATEGIES IN MANAGING THE RISK OF BACTERIAL ENDOCARDITIS
No full textAim: to assess awareness about the correlation between oral
hygiene and bacterial endocarditis among the population and
healthcare professionals, exploring prevention and risk management strategies.
Methods: two questionnaires with Google Forms were developed: an 11-question questionnaire administered to 377 potential
patients and a 9-question questionnaire addressed to 30 healthcare professionals to analyze knowledge and habits. In addition,
a clinical case of patient with a congenital heart valve defect who
had undergone twice valve replacements and was therefore at
high risk of endocarditis was studied. She presented with a hairy
tongue, halitosis, and high levels of gingival pathogens. Treatment included professional oral hygiene, photodynamic therapy
and probiotics, with bacterial load monitoring.
Results: 50.4% of patients showed limited knowledge of the
correlation between oral hygiene and cardiovascular risk, while
28.6% were unaware of it. Among professionals, 93.3% considered themselves very informed, but 20% did not broach the
subject with patients. In the clinical case, high levels of E. corrodens and C. hominis were found, bacteria from green complex strictly associated with endocarditis. After treatment, an
improvement in lingual condition and a reduction in oral bacterial load from 20% to 11% was observed.
Conclusions: data highlight the need for a multidisciplinary
approach to the prevention of bacterial endocarditis. Photodynamic therapy and probiotics showed potential in risk
management and should be further investigated in clinical
settings
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