1,721,273 research outputs found
Can reasoned mass testing impact covid-19 outcomes in wide community contexts?An evidence-based opinion: Mass testing and outcomes of COVID-19 in Lombardy and Veneto
Full text linkWe describe the early phases of a COVID-19 epidemic in two contiguous Italian regions, Lombardy and Veneto, which were heavily and simultaneously hit by SARS-CoV-2 in Italy but showed markedly different disease outcome in terms of case fatality rate, SARS-CoV-2-attributable mortality and hospitalization. We discuss data limitations together with similarities and differences of the regional context possibly affecting COVID-19 control in the two regions. We conclude that the better COVID-19 outcome in Veneto was due, at least in part, to the adoption of a strategy of active search of asymptomatic SARS-CoV-2 infections (Reasoned Mass Testing), instead of a strategy strictly based on the detection of symptomatic cases
La perequazione infrastrutturale nell’ambito delle politiche regionali: l’esperienza del FAS
No full textQuesto contributo esamina le chiavi di riparto stabilite per la ripartizione del Fondo per le Aree Sottoutilizzate (FAS) che hanno caratterizzato i due cicli di programmazione della politica regionale 2001-2006 e 2007-2013. Lo scopo è quello di fornire elementi di analisi e di riflessione per il nuovo ciclo di programmazione, che richiederà una nuova fase di negoziazione
tra stato e regioni per la definizione di nuove chiavi di riparto. I nuovi riferimenti normativi, le scelte tecnico-statistiche per il calcolo degli indicatori di riferimento e il nuovo quadro economico genereranno, infatti, una allocazione inter-regionale delle risorse molto diversa da quella attuale
The lipopeptide antymicotic, cilofungin modulates the incorporation of glucan associated proteins into cell wall of Candida albicans.
No full textThe effect of the β 1–3 glucan synthase inhibitor, cilofungin, on the incorporation of 35S-methionine-labelled glucan associated proteins (GAP) in the cell wall of Candida albicans was investigated in a susceptible strain C. albicans 3153 and resistant strain C. albicans CA-2. Cilofungin exerted a marked effect on the GAP composition of the cell wall at 0⋅25 mg/L, a concentration which reduced β 1/3 glucan synthesis by approximately 50% and also inhibited the growth of the susceptible strain C. albicans 3153. A 46 kDa protein was present in large amounts in C. albicans 3153 but not in strain CA-2. This protein was probably not mannosylated and its incorporation was greatly reduced by cilofungin. In addition, a well defined 34 kDa protein was identified together with a distinct band of high molecular mass polydisperse material of between 65 and 96 kDa and another of > 200 kDa. These proteins were strongly reactive to concanavalin A indicating that they were mannosylated, and treatment with cilofungin caused an increase in their production which was also confirmed by immunoblotting with rabbit anti-Candida serum. In contrast, exposure of the drug-resistant strain CA-2 to cilofungin did not result in changes in the composition of the GAP constituents. Only the mannosylated proteins of 34 kDa and the high molecular mass polydisperse material 65–96 kDa were present in the cell wall. The pulse-chase labelling experiments showed that the 46 kDa protein was the first of the GAPs to be incorporated into the cell wall, and that this was suppressed in the presence of cilofungin whereas there was a concomitant increase in the incorporation of the 34 kDa and the high-molecular weight polydisperse material. Thus, cilofungin causes a profound imbalance in GAP incorporation into the growing cell wall which is possibly related to changes in the amount and type of glucan being synthesized at sub-inhibitory concentrations of the antimycotic
Tax Evasion across Italy: Rational Noncompliance or Inadequate Civic Concern
No full textThe paper suggests an explanation for the geographical dimension of tax evasion that focuses on the structure of territorial government. Taxes administered by the central government are not differentiated by regions. Poor areas may prefer a combination of lower taxes and lower levels of public services at both the central and the local level. This is especially true when income and wealth levels differ among the areas and the demand for publicly provided goods is correlated to these levels. But the use of nationally uniform tax schedules imposes a welfare burden on poorer areas. While the tax rates of local taxes can be adjusted to local preferences, tax evasion may be tacitly accepted as a compensation for the welfare loss deriving from too high centrally set tax rates
Proximal tibia reconstruction with cementless modular prosthesis after resections for bone tumors [Reconstrucao da tibia proximal com protese modular nao cimentada apos resseccao de tumores osseos]
No full textThe authors analyzed 68 patients at Istituto Ortopedico Rizzoli between 1985 and 1993 with primary bone tumors of proximal tibia submitted to resection and reconstruction with cementless modular prosthesis. With a medium follow-up of 52 months, the functional results were excellent and good in 75% of cases according to Eneking's classification, employed by the Musculoskeletal Tumor Society. The mechanical complications were more common (30%), however, the resolution did not change the functional status. Of those who developed infection (11 cases), only 50% had good results. Based on the excellent functional results obtained, the authors conclude that cementless modular prosthesis is a reasonable reconstructive option after resection of proximal tibial tumors. The extensor mechanism reconstruction and the prosthetic muscular covering are essential factors to obtain those results
Antimorphogenic effects of 2-deoxy-d-glucose in Candida albicans.
No full textAbstract 2-Deoxy-d-glucose (dGlc) is able to inhibit both N-acetyl-hexosamine-induced chlamydosporogenesis and N-acetyl-glucosamine- or proline-induced germ-tube formation in Candida albicans. This inhibition is exerted also at dGlc concentrations which do not affect growth in the yeast form and do not reduce either the uptake or the incorporation of N-acetyl-d-glucosamine (GlcNAc) into yeast or hyphal cell material. Inhibition of germtube formation by dGlc does not occur in serum and is fully reversed by glucose. It is suggested that dGlc acts as a potent antimorphogenic effector in C. albicans
Assay for the identification and quantification of clamydia pneumonia in atherosclerotic plaques by lightcycler real-time pcr
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