1,720,985 research outputs found
Arginine and glycine stimulate creatine synthesis in creatine transporter 1-deficient lymphoblasts
No full textCreatine transporter 1 (CT1) defect is an X-linked disease that causes severe neurological impairment. No treatment has been available for this condition so far. Because the transport of creatine (Cr) precursors Gly and Arg is not affected in this disorder, we tested the possible corrective effect of these two amino acids on Cr depletion in lymphoblasts lacking the transporter. Substrates enriched with Arg or Arg plus Gly increased the concentration of intracellular Cr in affected cells as well as in control cells. The greatest effect was obtained with 10 and 15 mM Arg and 10 mM Arg plus Gly. These results encourage an in vivo trial with Cr precursors in CT1 defect
Foglio 467 “Salerno” Cartografia Geologica Autorità di Bacino del Sarno. Scala 1:10.000
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Psychometric properties of Movement Disorder-Childhood Rating Scale
No full textBackground:
Movement Disorder‐Childhood Rating Scales (MD‐CRS) have been designed in two forms (0–3 and 4–18y) to evaluate various movement disorders in children by Battini et al. The ability of MD‐CRS to capture changes during treatment was tested for both scales with various longitudinal studies and case report studies.
Aim:
Evaluate psychometric properties of MD‐CRS reliability when used by clinicians without a complete knowledge of this tool.
Methods:
After brief training in scoring MD‐CRS, three clinicians (a resident doctor, a child neurologist and a physical therapist) independently scored 20 patient videotapes, of children with movement disorders. In addition, the resident doctor scored 40 videos of 20 patients evaluated twice for test‐retest. Reliability was assessed by Intraclass Correlation Coefficient (ICC), Standard Error of Measurement (SEM) and Minimal Detectable Difference (MDD) and was calculated separately for the two forms of the scale and for each score (Index I, Index II and Global Index).
Results:
for both forms, inter‐rater reliability of Global Index and Index I were good with an ICC ranged between 0.72 and 0.95 and a SEM ranged between 0.04 and 0.06. Instead, results of Index II were substantially moderate for both forms, with an ICC of 0.60 and 0.50, respectively and SEM values were 0.16.. Test‐retest reliability values for all Indexes in both forms showed excellent values with ICCs ranging from 0.95 to 0.99. MDD values were between 0.04 and 0.12.
Conclusion:
MD‐CRS 0–3 and MD‐CRS 4–18 remain reliable clinical measurement tools for evaluation of MD in developmental age when used by clinicians without a specific knowledge after specialized training
Efficacy of vigabatrin intervention in a mild phenotypic expression of succinic semialdehyde dehydrogenase deficiency.
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