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Miocardiopatia não compactada: um relato de caso em atleta de alto rendimento
Get PDFNoncompaction cardiomyopathy (NCM) is characterized by the presence of abnormal
trabeculations in the left ventricle (LV), most commonly in the apex, which may be associated
with LV dilation or hypertrophy, or other congenital heart diseases. Objective: Describe the
clinical and diagnosis of non-compaction cardiomyopathy, as well as the treatment and
prognosis of the patient. Case report: M.L.S, female, swimming athlete, 100 and 200m crawl
and back tests, in 2010, at 16 years of age, in outpatient care for suspected cyst in the right
wrist, a possible arrhythmia was questioned on physical examination. The requested
electrocardiogram (ECG) was normal, however, magnetic resonance imaging (MRI) and
echocardiogram showed elevated trabeculations in the middle and apical portion of the left
ventricular (LV) lateral wall, with relation between the non-compacted myocardium on the
compacted myocardium was 2,7, diagnosed with non-compacted cardiomyopathy (MNC).
Even asymptomatic, acetylsalicylic acid (ASA) and interruption of sports competitions were
recommended. Discussion: MNC is considered a rare and congenital heart disease, due to
non-compression of the myocardium, possibly between the fifth and eighth embryonic weeks.
MNC can be found in 3% of patients with reduced ejection fraction and heart failure, and in
up to 8% of athletes. Conclusion: More scientific studies on MNC are needed in
asymptomatic patients, such as the patient studied, as a way to contribute to a better
understanding of the management of athlete patients and the possible evolution to a
symptomatic picture with possible complications.A Miocardiopatia não Compactada (MNC) é caracterizada pela presença de trabeculações
anormais no ventrículo esquerdo (VE), mais comumente encontradas no ápice, podendo estar
associada a dilatação ou hipertrofia do VE, além de outras cardiopatias congênitas. Objetivo:
Descrever o quadro clínico e diagnóstico da miocardiopatia não compactada, bem como o
tratamento e prognóstico da paciente. Relato de caso: M.L.S, feminino, atleta de natação,
provas de 100 e 200m crawl e costas, em 2010, aos 16 anos de idade, em atendimento
ambulatorial por suspeita de cisto em punho direito, ao exame físico foi questionada uma
possível arritmia. O eletrocardiograma (ECG) solicitado veio sem alterações, descartando
arritmia, contudo, na ressonância magnética (RM) e no ecocardiograma foram identificadas
acentuadas trabeculações na porção média e apical da parede lateral do ventrículo esquerdo
(VE), com relação entre o miocárdio não compactado sobre o miocárdio compactado de 2,7,
sendo diagnosticada com Miocardiopatia não compactada (MNC). Mesmo assintomática, foi
preconizado uso continuo de ácido acetilsalicílico (AAS) e interrupção das competições
esportivas. Discussão: A MNC é considerada uma cardiopatia rara e congênita, decorrente da
não compactação do miocárdio, possivelmente entre a quinta e oitava semana embrionária.
Acredita-se que pode ser encontrada em 3% dos pacientes com fração de ejeção reduzida e
insuficiência cardíaca, e em até 8% dos atletas. Conclusão: É necessário mais estudos
científicos sobre a MNC em pacientes assintomáticos, como a paciente estudada, como forma
de contribuir para o melhor entendimento do manejo de pacientes atletas e da possível
evolução para um quadro sintomático com possíveis complicações
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Atividade de Calophyllum brasiliense sobre Leishmania (Viannia) braziliensis : estudo de alterações ultra-estruturais e bioquímicas
No full textOrientador: Prof.ª Dr.ª Maria Valdrinez Campana LonardoniTese (doutorado em Biociências e Fisiopatologia) - Universidade Estadual de Maringá, 2016RESUMO: As leishmanioses são doenças infecciosas causadas por protozoários do gênero Leishmania que afetam mais de 12 milhões de pessoas mundialmente, e apresentam alta endemicidade, morbidade e mortalidade em populações da África, Ásia e América Latina. Os antimoniais pentavalentes, a anfotericina B e as pentamidinas são as substâncias mais utilizadas para o tratamento da leishmaniose, porém possuem custo elevado e toxicidade para o coração, rins, fígado. Além disso, os medicamentos são de difícil administração e podem apresentar falha terapêutica e resistência do parasito. Nos últimos anos, os produtos naturais, especialmente derivados de plantas, têm sido considerados como potenciais alternativa para o tratamento da leishmaniose, visando o desenvolvimento de novas drogas que apresentem maior atividade e menor toxicidade. A espécie vegetal Calophyllum brasiliense Cambess, planta da família Clusiaceae, é uma árvore de grande porte, que cresce principalmente em regiões de floresta da Mata Atlântica no Brasil. Alguns estudos relataram as propriedades antibacterianas do C. brasiliense emBacilus cereus e Staphylococcus epidermitis, antiparasitárias, como para camundongos BALB/c infectados com Leishmania. (Leishmania) amazonensis. Assim, neste estudo foram avaliados os efeitos do extrato de C. brasiliense e da cumarina (-) mammea A/BB, derivado desta planta, na indução de morte de formas promastigotas de Leishmania (Viannia) braziliensis. As análises por microscopia eletrônica de transmissão e de varredura revelaram que o tratamento com C. brasiliensis induziu alterações ultra-estruturais em formas promastigotas, foram visualizadas alterações mitocondriais como a redução na densidade da matriz mitocondrial, inchaço mitocondrial, vacuolização citoplasmática, vacúolos autofágicos atípicos, condensação da cromatina anormal e a presença de muitos vacúolos lipídicos. Após o tratamento com C. brasiliense, também foram observadas características bioquímicas relacionadas com a apoptose, como a fragmentação do DNA, suspensão do ciclo celular, perda da integridade da membrana, despolarização da membrana mitocondrial e aumento da produção de reativos de oxigênio. Esses resultados sugerem que o extrato de C. brasiliense e a cumarina (-) mammea A/BB induzem alterações sugestivas de morte celular por apoptose em formas promastigotas de L. (V.) braziliensis e são candidatos promissores para o desenvolvimento de novos agentes terapêuticos para as leishmaniosesABSTRACT: Leishmaniasis is infectious diseases caused by protozoa of the genus Leishmania that affect more than 12 million people worldwide and feature high endemicity, morbidity, and mortality in populations of Africa, Asia, and Latin America.Treatment of leishmaniasis is made based on pentavalent antimony, Amphotericin B, and pentamidine, which are costly, are toxic to the heart, kidneys, liver, difficult to administer and can cause resistance to the parasite. In recent years, natural products, especially plant derivatives have aroused interest in the search for alternative therapies for the treatment of leishmaniasis, with the aim of developing new drugs, which have higher activity and lower toxicity. The Calophyllum brasiliense Cambess, Clusiaceae family plant, is a large tree, which grows mainly in the Atlantic Forest of forest areas in Brazil. Some studies have shown that the properties of the plant include antibacterial activity against Bacillus cereus and Staphylococcus epidermitis, cytotoxic activity on some lines of tumor cells and antimicrobial in BALB / c mice infected with L. (L.) amazonensis.In the present study, it was evaluated the activity of C. brasiliense and coumarin (-) mammea A/BB in inducing cell death in promastigotes of L. (V.) braziliensis. Scanning electron and scanning microscopy revealed that the treatment with C. brasiliensis induced ultrastuctural changes in the parasite, as vacuolation, mitochondrial changes, such as reducing the density of the mitochondrial matrix, mitochondrial swelling, atypical autophagic vacuoles, abnormal chromatin condensation and presence of many lipid vacuoles.It was also possible to observe biochemical characteristics associated with apoptosis such as DNA fragmentation, cell cycle suspension, loss of membrane integrity, mitochondrial membrane depolarization and increased production of ROS.These results suggest that C. brasiliense coumarin extract and (-) mammea A / BB induce changes suggestive of apoptotic cell death in promastigotes of L. (V.) braziliensi and are promising candidates for the development of new therapeutic agents for leishmaniasis78 f. : il. (algumas color.)
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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