1,720,964 research outputs found
Zoledronic acid decreases mRNA six-transmembrane epithelial antigen of prostate protein expression in prostate cancer cells
No full textEvaluation of cell apoptosis and Cox-2 expression in glucocorticoid-induced osteoporosis in rats treated with risedronate
No full textAltered bone metabolism of idiopathic hypercalciuria - A possible role for nitric oxide
No full textThe pathogenesis of idiopathic hypercalciuria has not yet elucidated, but a correlation between hypercalciuria and altered bone metabolism has been proposed. Since nitric oxide (NO) modifies osteoclasts' activity, a possible role for NO in the control of bone metabolism and in the pathophysiology of idiopathic hypercalciuria (Hi) can be suggested. To test this hypothesis, 49 patients affected by IH, on normal calcium diet (NCD) were assayed for plasma levels of creatinine (Cr), Ca++, ALP, b-ALP, PTH, calcitriol, BGP, along with 24 hrs urinary excretion of Cr, hydroxyproline (uHP), nitrite and nitrate (NO2-/NO3-). uHP was also evaluated in a spot urine sample either during NCD or after low calcium diet (LCD). Following LCD, Hi patients were grouped in fasting IH (FH) and absorptive IH CAH). Vertebral BMD in IH was lower vs controls (C), (Zscore=-0.92+/-0.17 us 0.27+/-0.25, p<0.002). PTH, calcitriol and BGP were not different in FH or AH and C. FH showed an increase in b-ALP us C (34.4+/-2.3 us 25.9+/-2.3 Un, p<0.03), and higher uHP in spot urines, either on NCD (14.1+/-0.7 vs 9.2+/-0.8 mg/g uCr, p<0.01) or after LCD (22.0+/-1.2 us 16.9+/-1.7, p<0.05). Interestingly, NO2-/NO3- urinary excretion in FH was lower vs AH and C (0.238+/-0.021 vs 0.273+/-0.022 mmol/mmol uCr, p<0.001, and vs 0.281+/-0.019, p<0.001), with no difference between AH and C. This study confirm the presence of an altered bone metabolism and lower BMD in FH and the decreased NO production in FH could participate to their higher bone turnove
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The effects of vitam D receptor polymorphism on secondary hyperparathyroidism and bone density after renal transplantation.
No full textI. F. 6.52
Differential characteristics of bone quality and bone turnover biochemical markers in patients with hip fragility fractures and hip osteoarthritis: results of a clinical pilot study
No full textBackground and aims: Bone density and quality alterations worsen the ability of osteoporotic bone to support prosthetic implants. The aim of our study was to evaluate potential differences in bone quality and bone turnover markers in aged individuals undergoing surgery for hip fragility fracture or hip osteoarthritis. Methods: Eighteen subjects with hip fragility fractures (Hip Fracture Group), 35 subjects with osteoarthritis of the hip (Hip Osteoarthritis Group) and 19 subjects with normal femoral bone mineral density (Control Group) were evaluated. Serum and urinary bone markers were assayed preoperatively in all surgical patients, and within 48 hours after fracture in the Hip Fracture, Osteoarthritis and Control groups. Histomorphometric analysis was performed on surgical samples. Results: A significant alteration in calcium and PTH serum levels with hyperparathyroidism was observed in the Hip Fracture Group compared with Hip Osteoarthritis and Control Groups. C-Terminal telopeptides of type I-collagen (CTx) and tartrate resistant-acid phosphatase (TRAP), markers of bone resorption, were increased in the Hip Fracture Group compared with both Osteoarthritis and Control Groups (CTx: p<0.0007 and p<0.0039 respectively; TRAP: p<0.002 and p<0.0007). All subjects were vitamin D(3)-deficient, but no differences were found among the different groups. In addition, histomorphometric data showed better maintained connectivity in the Osteoarthritis Group compared with the Hip Fracture Group (p<0.0001). Conclusions: Our data show significant differences in bone turnover markers in patients undergoing hip prosthesis for fragility fractures, compared with patients operated for hip osteoarthritis. (Aging Clin Exp Res 2011; 23: 99-105) (C)2011, Editrice Kurti
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