1,720,963 research outputs found
Ruolo della chemioembolizzazione intra-arteriosa (TACE) con microsfere a rilascio di Irinotecano (DEBIRI) nel trattamento delle metastasi epatiche da melanoma dell’uvea
No full textScopo:
Il 50% circa dei pazienti con melanoma dell’uvea (UV) svilupperà metastasi, in prevalenza epatiche.
La prognosi dei melanomi uveali metastatici (mUM) è severa e, ad oggi, non vi è una terapia
standard.
Materiali e metodi:
Sono stati analizzati in modo prospettico i dati di 141 pazienti con mUM sottoposti, come approccio
iniziale, a TACE con DEBIRI (12,1%), terapia sistemica (39,7%), entrambe (33,3%) o nessuna delle
due (14,9%) da Settembre 1990 a Settembre 2013.
Risultati:
Il tempo medio libero da malattia è stato di 23,1 mesi, la sopravvivenza media dei pazienti in IV
stadio è stata di 18,1 mesi. La percentuale di coinvolgimento epatico (RR 1.3), la presenza di
malattia multi organo (RR 2.0), l’incremento dei livelli di LDH (RR 1.8) ed un performance status
secondo i criteri WHO pari a 1 (RR 1.6) o 2-3 (RR 4,7) sono stati associati ad una prognosi peggiore.
In presenza di lunghi intervalli liberi da malattia (RR 0.9), il ricorso a TACE con DEBIRI nel
trattamento delle metastasi epatiche ha determinato un incremento della sopravvivenza (22,6 mesi)
rispetto alle sole chemioterapie sistemiche (14.4 mesi). In particolare la combinazione di DEBIRI
TACE con fotemustina per via sistemica ha determinato il maggiore incremento della sopravvivenza
(RR 0,5).
Conclusioni:
La prognosi dei melanomi uveali metastatici è influenzata da: percentuale di coinvolgimento epatico,
presenza di malattia multiorgano, livelli di LDH, performance status, intervallo libero da malattia e
dalla terapia loco regionale con DEBIRI
Characterization of a case of virological failure after switch to long-acting cabotegravir and rilpivirine
No full textChemoembolization in Conjunction with Bevacizumab: Preliminary Results
No full textTransarterial chemoembolization is an effective, minimally invasive therapy that is widely used for treatment of unresectable colorectal cancer liver metastases (CRC-LM). However, chemoembolization induces a hypoxic microenvironment, which increases neoangiogenesis and may promote early progression. For this reason, transarterial chemoembolization efficacy may be improved by combining it with an angiogenesis inhibitor, such as bevacizumab. This report shows that transarterial chemoembolization with irinotecan-loaded polyethylene glycol embolics and bevacizumab therapy was effective and well tolerated by 6 patients with CRC-LM, resulting in a disease control rate of 83% and an overall improvement in quality of life
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Chemoembolization Adopting Polyethylene Glycol Drug-Eluting Embolics Loaded With Doxorubicin for the Treatment of Hepatocellular Carcinoma
Full text linkThe purpose of this study is to determine the efficacy and tolerability of transarterial chemoembolization (TACE) using polyethylene glycol (PEG) drug-elutable microspheres loaded with doxorubicin for treatment of hepatocellular carcinoma (HCC)
Multidisciplinary approach of colorectal cancer liver metastases
Full text linkLarge bowel cancer is a worldwide public health challenge. More than one third of patients present an advanced stage of disease at diagnosis and the liver is the most common site of metastases. Selection criteria for early diagnosis, chemotherapy and surgery have been recently expanded. The definition of resectability remains unclear. The presence of metastases is the most significant prognostic factor. For this reason the surgical resection of hepatic metastases is the leading treatment. The most appropriate resection approach remains to be defined. The two step and simultaneous resection processes of both primary and metastases have comparable survival long-term outcomes. The advent of targeted biological chemotherapeutic agents and the development of loco-regional therapies (chemoembolization, thermal ablation, arterial infusion chemotherapy) contribute to extend favorable results. Standardized evidence-based protocols are missing, hence optimal management of hepatic metastases should be single patient tailored and decided by a multidisciplinary team. This article reviews the outcomes of resection, systemic and loco-regional therapies of liver metastases originating from large bowel cancer
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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