1,721,203 research outputs found
Interferonopathy: A potential link between innate immunity and autoimmunity in the pathogenesis of COPD
No full textDrugs for the Treatment of Airway Disease
No full textCOPD, asthma, corticosteroids, bronchodilators, monoclonal antibodie
Chemokine receptor inhibitors as a novel option in treatment of asthma
No full textThe migration of cells towards and into the site of an inflammatory insult is critical for maintenance of the inflammatory response and its resolution. This is particularly so in the case of asthma where recruitment of key effector cells may control disease severity, responsiveness to current therapies and the airway remodelling associated with the disease. Chemokine receptor antagonists have the hope of preventing inflammatory cell recruitment to the airway and perhaps as a consequence affect the resolution of airway remodelling. A number of selective antagonists directed at various CC and CXC receptors thought to be important in asthma are currently at various stages of clinical development. Results from these studies will determine whether chemokine receptor antagonists will prove beneficial in severe glucocorticoid-dependent and -resistant asthmatic subjects. Furthermore, it is possible that early treatment with these agents may prevent the disease from becoming established. © 2004 Bentham Science Publishers Ltd
Commentary on "Major Complications Associated with Conventional Transbronchial Needle Aspiration"
No full textCARATTERISTICHE ECOLOGICHE DELLA NURSERY DI FOCE ADIGE
No full textA survey was carried out in a Tapes philippinarum nursery located at Foce Adige (northern Adriatic Sea). Four sampling campaigns were carried out between 2007 and 2008 with the aim of determining the standing stock and distribution of young clams. Water and sediment parameters were also determinated. In summer 2008, an exceptional freshwater flow almost depauperated the whole nurser
Breaking news: DNA damage and repair pathways in COPD and implications for pathogenesis and treatment
No full textChanging pharmacological approaches in mild asthma
No full textCurrent International and National guidelines on the management of asthma recommend a regular treatment with low doses of inhaled corticosteroids for patients with mild persistent asthma to achieve asthma control and reduce the risks of severe asthma exacerbations. However, recent clinical trials have hampered the traditional view that all patients with mild persistent asthma should be treated regularly with low doses of inhaled corticosteroids. Different strategies for the treatment of these patients have been recently proposed. Promising results have come from clinical trials that have tested different options, including the combination of inhaled corticosteroids and long-acting β2-agonists, oral leukotriene antagonist, and the intermittent or as-needed use of inhaled corticosteroids in the absence of regular treatment. Conversely, pharmacological approaches/strategies other than as-needed bronchodilation still need to be tested for the vast population of patients with mild intermittent asthma
Glucocorticoidi per via inalatoria nel trattamento della patologia polmonare dell’adulto.
No full textn/
Evaluation by self-monitoring and noninvasive measures
No full textAsthma severity may be defined in various ways. Despite common perception, well-controlled asthma is not synonymous with mild asthma and poorly controlled asthma is not synonymous with severe asthma. Symptoms cannot always be used as the only criteria of severity since the individual tolerance to a given degree of airflow limitation is variable. There are three asthma phenotypes which are generally defined as difficult to treat asthma: brittle asthma, systemic glucocorticoid-dependent asthma, and glucocorticoid-resistant asthma. This article reviews the role of self-monitoring and noninvasive measures in the diagnosis and treatment of difficult to control asthma and therapy-resistant asthma. An objective measure of the overall asthma severity is essential in the diagnosis and treatment of difficult to control asthma and therapy-resistant asthma, because the goal of asthma control is based on self-monitoring/noninvasive measures, essentially history and lung function tests. The role of ..
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