1,722,083 research outputs found
Best free communications" per il contributo: Fedele, F., Caputo, A., & Langher, V. (2018). Desiderio di maternità e infertilità: Analisi delle narrazioni di pazienti in trattamento di Procreazione Medicalmente Assistita. 1° Congresso Nazionale "Procreazione Medicalmente Assistita", PMA Italia, Firenze, 23-24 Febbraio 2018
No full text
Le arti, il linguaggio e lestetica-ermeneutica
No full textuna intervista su filosofia e altri linguagg
Emotional and symbolic components of hikikomori experience: A qualitative narrative study on social withdrawal
No full textHikikomori is a form of social withdrawal affecting adolescents and young adults that prevents social, school and work activities. The present study aims at expanding qualitative narrative research on such a social withdrawal from the participants' perspective, as to detect emotional and symbolic components of the hikikomori experience. Emotional Text Analysis was conducted on the narratives of 17 Italian people (9 men, 18-39 aged), who posted their hikikomori stories via an online forum. Statistical multidimensional techniques were performed to detect some thematic domains (Cluster Analysis) and latent factors organizing the contraposition between them (Multiple Correspondence Analysis). Five clusters emerged as follows: refusal of intimacy (cluster 1), retreat to passivity (cluster 2), search for comfort (cluster 3), interpersonal distress (cluster 4), and performance anxiety (cluster 5). Then, four latent factors were identified dealing with a complex of dependency, tendency to introversion, refusal of agency, and ambivalence towards intimacy, respectively. The results provide new insights on the complexity and awareness of the affective experience of hikikomori to be integrated with the existing evidence in the literature
Addiction, locus of control and health status: a study on patients with substance use disorder in recovery settings
No full textObjective: This study aims at testing (a) the association between locus of control and socio-demographic, drug use, and treatment-related variables in patients with drug addiction following rehabilitation, and (b) whether locus of control may account for physical and mental health status also controlling for social desirability responding. Methods: Seventy-eight participants were recruited within therapeutic communities for drug rehabilitation treatment. They completed measures of locus of control (LCB), health-related status (SF-12) and social desirability responding (BIDR-6 short form) and provided further socio-demographic, drug use, and treatment-related information. T-tests, Pearson’s correlations, and hierarchical regression analyses were conducted. Results: Education and treatment duration represent the only two meaningful factors potentially favoring higher internal locus of control. Locus of control results to be a predictor of mental health status, explaining for about 6.5% of the outcome variance. However, when considering the potential influence of social desirability responding such a relationship does not remain statistically significant anymore. Conclusion: The study provides some insights about the relationship between locus of control and individual and treatment-related variables, that could be further explored to promote treatment success in rehabilitation programs. As well, social desirability arises as a major concern to be handled when dealing with substance use populations
Dall'essere al dono. Paul Ricoeur e le sfide dell'ontoteologia
No full textSi propone un percorso ontologico su Paul Ricoeu
Psychodynamic insights from narratives of people with amyotrophic lateral sclerosis: A qualitative phenomenological study
Full text linkThis study explored the illness experience of people with amyotrophic lateral sclerosis (ALS) to widen narrative research on patients’ perspectives, adopting object relations theory as interpretative framework. A qualitative phenomenological analysis was conducted on the illness stories of 12 adult Italian patients with ALS, collected through an Internet-based database for the sharing of illness experiences of people with rare and chronic degenerative diseases. Three thematic areas were identified: “the experience of ALS from symptom onset to diagnosis”, “impact of illness”, and “coping with illness”. Overall, the central conflict experienced by people with ALS refers to the progressive loss of control on bodily experience, that is handled by means of denial and splitting defences to contrast such a process of somatic depersonalization. As well, the investment on interpersonal domain responds to a repairing strategy ensuring psychic vitality and sensorial integration to rebuild the relation between the self and the external world
EDITORIAL: MANAGEMENT OF CYTOLOGICAL BIOMATERIALS IN PREDICTIVE PATHOLOGY
Full text linkThe assessment of predictive biomarkers is an obligatory step in the diagnosis of non-small-cell lung cancer (NSCLC) (1). More than half of NSCLC are not eligible for surgical treatment and many of them are not reachable by forceps or brush during bronchoscopy. For these reasons, cytological samples, mainly obtained by fine-needle aspiration cytology (FNAC) or small biopsies by slightly larger gauges, represent most of the samples available for the assessment of predictive biomarkers other than for preliminary accurate diagnoses. Routinely applied algorithms for predictive biomarkers include genetic targets or their phenotypic expression, tested by different procedures. Therefore, careful management is necessary to optimize the exiguous materials represented by cytological samples.
Among the targetable mutations of NSCLC, epidermal growth factor receptor (EGFR) ranges, in Europe, around 15% and a definitive smaller proportion of EGFR-wild NSCLC, harbours rearrangements of ALK or ROS1 genes (1). In the absence of any targetable mutation, NSCLC may be treated by immunotherapy, provided that the programmed death‐ligand 1 (PD‐L1) expression has been tested on the same samples. Therefore, it is mandatory to identify NSCLC carrying any of these genetic alterations to enable corresponding patients to access optimal treatments and avoid side effects of less effective agents. It is also important to timely assess the negativity of these tests, in most of the patients, to hasten traditional treatments. In the meantime, researchers and industries are searching and hopefully finding new molecular targets and potential corresponding drugs; it is foreseeable that their number will increase in a near future as well as the corresponding diagnostic needs (2). Therefore, pathologists will deal more and more with small samples to satisfy increasing requests.
Next-generation sequencing (NGS) and high-throughput technologies (HTT) may overcome these limitations and difficulties provided that enough and good quality genetic material is available (3). It has been calculated that 40 ng of good quality DNA is enough for any genetic testing and this quantity can be yielded by a single pass of FNAC (4,5). Traditionally DNA and RNA are routinely extracted separately from tissues or smears and multiple primer pairs are utilized to capture the gene targets by PCR to prepare distinct DNA and RNA libraries for separate downstream sequencing (6). New technologies allow to extract and process both nucleic acids simultaneously (7,8). Therefore, in a near future, new technologies will probably overcome the limitations and difficulties caused by the small size of diagnostic samples but, to date, most laboratories perform in sequential mode the requested genetical tests including ALK and ROS1 evaluation. In fact, although different techniques can be used to identify ALK- and ROS1-rearranged NSCLC, immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are the mainstays in most of the labs so far; namely ALK and ROS1 are tested by ICC and validated by FISH on single sections. In this issue, the article by Zito Marino et al (9) have tested and validated a multiplex ALK/ROS1 FISH approach in NSCLC on a FNAC series compared with the ALK and ROS1 status previously assessed by classic FISH test using single break apart probes and IHC. In their study (10) the dual ALK/ROS1 FISH probe test results have been fully concordant with the results of previous single ALK and ROS1 FISH tests on different slides. Therefore, the authors have further demonstrated that multiplex ALK/ROS1 FISH probe test can detect simultaneously ALK- and ROS1-rearrangement on a single slide sparing precious material for other tests (9,10). The first author of the study, Dr. Federica Zito Marino PhD, biologist in the Pathology Unit of Università degli Studi della Campania “L. Vanvitelli”, has received an award by BIOPTICA SPA for a recent work (11), in which the authors validated the multiplex FISH technique on cytological samples, often representing the only available biomaterial for non-small cell lung cancer patients, opening new diagnostic perspectives in the predictive pathology. The Award will be delivered during the course “Il confine tra benigno e maligno”, to be held in Sorrento on October 5-7 2020.
In conclusion, waiting for automated technologies that will provide multiple assessment by a single procedure, multitargets FISH approach in NSCLC can optimize the assessment of predictive biomarkers, namely ALK/ROS1 status, in terms of time, costs and conferring a great help to cases with a limited number of neoplastic cells as it may happen with cytological samples
Filosofia e musica
No full textUn percorso che mette in parallelo le svolte della storia della filosofia e quelle della storia della music
- …
