1,721,062 research outputs found
Mammalian Transglutaminases. Identification of substrates as a key to physiological function and physiopathological relevance.
No full textTransglutaminases form a large family of intracellular and extracellular enzymes that catalyse the Ca2+-dependent post-translational modification of proteins. Despite significant advances in our understanding of the biological role of most mammalian transglutaminase isoforms, recent findings suggest new scenarios, most notably for the ubiquitous tissue transglutaminase. It is becoming apparent that some transglutaminases, normally expressed at low levels in many tissue types, are activated and/or overexpressed in a variety of diseases, thereby resulting in enhanced concentrations of cross-linked proteins. As applies to all enzymes that exert their metabolic function by modifying the properties of target proteins, the identification and characterization of the modified proteins will cast light on the functions of transglutaminases and their involvement in human diseases. In this paper we review data on the properties of mammalian transglutaminases, particularly as regards their protein substrates and the relevance of transglutaminase-catalysed reactions in physiological and disease conditions
Antibodies against type 2 transglutaminase modulate actin rearrangements and cell cycle in several cell lines
No full textRat prostate transglutaminase: biochemical properties of recombinant forms expressed into COS-1 cells
No full textStudio del riconoscimento tra transglutaminasi di tipo 2 e auto-anticorpi anti-transglutaminasi caratteristici della malattia celiaca
No full textTissue transglutaminase modulators regulate actin rearrangements and cell cycle in several cell types
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PREDICTION AND ANALYSIS OF IDIOTYPE-ANTI-IDIOTYPE ANTIBODY COMPLEXES ASSOCIATED TO CELIAC DISEASE
No full textCharacterisation of rat coagulating gland transglutaminase expressed in heterologous cell systems
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