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    An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation

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    Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C–C bond forming step
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