1,720,996 research outputs found
Determinazione dei farmaci anticoagulanti orali diretti in regime di urgenza. Determination of direct oral anticoagulant drugs in emergency. Guidelines for laboratory and istological diagnosis of celiac disease. Revision 2015.
No full textBackground: For over a year, even in Italy, are in use the new oral anticoagulants direct: dabigatran, a direct thrombin antagonist, and rivaroxaban, direct inhibitor of factor Xa. The advantage of these new drugs, with the same efficacy and safety compared to anticoagulants vitamin K antagonists, is due to their fixed-dose administration, the fewer drug interactions and no with the food, but most do not require monitoring of laboratory, if we exclude the periodic assessment of renal function. They have a short half-life, beginning and end of action fast. On the other hand, potential drawbacks regarding the use of these drugs are represented by the lack of antidotes in case of overdose or bleeding and the difficulty of controlling patient adherence. From a laboratory point of view the disadvantage is given by the difficulty of monitoring their effect with the current test, because the standard tests are not sufficient to provide an accurate answer, because of their poor or excessive sensitivity. Each Laboratory must therefore be organized in order to determine, in the presence of major bleeding events and/or to perform emergency surgery, the level of anticoagulation patient’s blood. The best way to answer the clinical question will therefore give the value of the drug present in that moment in the patient plasma. The purpose of this work is the development of the dosage of these drugs in the coagulometer available in our laboratory, in order to provide in the future, even in the regime of urgency, a quick response to the clinician. Methods: The methods for the assay of new oral anticoagulants direct were applied on the instrument BCS XP (Siemens Healthcare, Erlangen, Deutschland). The kit used for the quantitative determination of dabigatran is the BC Thrombin (Siemens Healthcare), the reagent used to assess the thrombin time in citrated human plasma. The method was suitably modified to provide a thrombin time defined diluted. The kit used for the quantitative determination of rivaroxaban is Berichrom Heparin (Siemens Healthcare) chromogenic assay specific for factor Xa. It was possible to build the appropriate calibration curves thanks to plasma calibrators and verificate with control plasma supplied by Hyphen BioMed (Neuville-sur-Oise, France). Results: The methods used are reliable and reproducible in a range between 24 and 497 ng/ml. Below 24 ng/ml will not be possible to give an exact value and values greater than 497 ng/ml, if required, will be necessary to dilute the sample. The coefficients of variation percentage intra-day and inter-day are all below 10% and the calibration curves have an r2=0.96. Conclusions: Our study shows that the methods selected and applied on coagulometer BCS XP in use in our laboratory are performed with the automatic procedure, in regime of urgency, in a time of about 30 minutes. The increase in the use of these drugs in clinical practice will help doctors to assess how the amount of the drug in plasma can be linked with the ability of the patient anticoagulant. © 2015, Springer-Verlag Italia
Quick Pocket Guide to New Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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