1,720,955 research outputs found
IgG diffusion through bioengineered materials for peripheral nerve regeneration
No full textIn successful nerve regeneration, sprouting axons from the proximal nerve stump traverse the injury site, and make new connections with target organs. Axons that fail to reach an appropriate end organ or fail to make a functional synapse will eventually undergo Wallerian degeneration. However, the incidence of recovery is highly variable, and the return of function is never complete. The use of synthetic nerve guidance channels show promises in improving the repair of injured human nerves, and the release of soluble bioactive agents like cytokines, may improve the degree and specificity of neural outgrowth [1]. The fibronectin (FN) guidance material has been already shown to promote axonal growth of sensory and other axons in rat spinal injuries in a way and to an extent not seen with any other non-graft implant to date. Ingrowth of new nerve tissue was dramatic in speed and content [2]. Also hyaluronan (HA) derivative HYAFF-11 (benzyl ester of Hyaluronic Acid) has been tested to be used for the bioartificial nerve guidance first of all because of its well documented biocompatibility and biodegradability and secondly because its particular physical-chemical properties make it processable in various three dimensional forms. Considering the role of the cytokine TGF-beta1 in scar formation and the potentially obtainable improved results in the repair of central and peripheral nervous system injuries with local delivery of neutralising antibody to the pro-fibrotic growth factor TGF-beta1, this study focuses mainly on the development of a new mathematical model to predict the diffusion of human antibody anti-TGF-beta1 through bioengineered membranes. In order to identify the model parameters, laboratory experiments have been set up, characterising the uptake and release of anti-TGF-beta1 to and from FN and HA synthetic nerve guidance channel
Data modeling for Tools and Technologies for the Analysis and Synthesis of NANOstructures (TASNANO) project
No full textThe main aim of TASNANO project is to focus on the development of a web-based system that allows
cooperative work between partners. Even if some commercial tools become available, the specificities of nanotechnology applications suggest implementing an ad-hoc tool. This approach permits to update information every moment, so that not only the latest versions of the documents are always available, but also the raw experimental data are shared in a protected environment. Organizing big amount of data begins with modelling of conceptual schemes, which individualizes entities involved into the project and links between them. The rules’ application of logic modeling leads to the production of a logic scheme. The model allows the data base design, which can be enlarged and enriched preserving coherence and avoiding redundancy. Data and information can be directly treated on the web in accordance with latest modifications
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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