86,647 research outputs found
Pharmacogenomics, pharmacokinetics and pharmacodinamics: interaction with biological differences between men and women
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Human male and female phenotypes depend on lifestyle (smoking and hormonal contraceptives): Implications for prevention and care
No full textOne drug does not fit all: Impact of sex and gender on pharmacological response
No full textIt is important to remember that gender health and illness should not to be conflated with women's health and illness. Turshen1 reports that numerous studies with 'gender' in the title use the word gender as a synonym for 'women' and as a result, men's gender-specific needs are missed. In addition, in reporting demographic characteristics of the study participants, some clinical trialists use the term 'gender' and some 'sex' to indicate men and women and this may create confusion. It can be difficult to separate the two concepts, because there are continuous and constant interactions and relationships between sex and gender3. In other words, sex and gender work together. However, little attention is paid to the fact that gender is a sex modifier. It is relevant to have in mind that both sex and gender affect health and illness4
Letter to the Editor in response to the article ‘Candidate drugs against SARS-CoV-2 and COVID-19’
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The Appropriateness of Medical Devices Is Strongly Influenced by Sex and Gender
No full textUntil now, research has been performed mainly in men, with a low recruitment of women; consequentially, biological, physiological, and physio-pathological mechanisms are less understood in women. Obviously, without data obtained on women, it is impossible to apply the results of research appropriately to women. This issue also applies to medical devices (MDs), and numerous problems linked to scarce pre-market research and clinical trials on MDs were evidenced after their introduction to the market. Globally, some MDs are less efficient in women than in men and sometimes MDs are less safe for women than men, although recently there has been a small but significant decrease in the sex and gender gap. As an example, cardiac resynchronization defibrillators seem to produce more beneficial effects in women than in men. It is also important to remember that MDs can impact the health of healthcare providers and this could occur in a sex- and gender-dependent manner. Recently, MDs’ complexity is rising, and to ensure their appropriate use they must have a sex–gender-sensitive approach. Unfortunately, the majority of physicians, healthcare providers, and developers of MDs still believe that the human population is only constituted by men. Therefore, to overcome the gender gap, a real collaboration between the inventors of MDs, health researchers, and health providers should be established to test MDs in female and male tissues, animals, and women
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