1,721,145 research outputs found
HCV: The best cure possible or the best possible cure?
No full textProgress in medicine goes along with an exponential growth of the cost of drugs and devices. While any person has the right to obtain the best possible benefit from medical care, a state needs to strike a balance between granting the optimal personal benefit to each individual and the needs of the society as a whole. Health systems in all countries therefore are facing a huge problem of distributive justice, as while they should guarantee individual rights, among which the right to health in its broader sense, including physical, psychological and social well-being (therefore not limited to healing, but extending to compliance and quality of life), they must also grant equal access to the healthcare resources and keep the distribution system sustainable
Mesalazine in the prevention of clinical and endoscopical postoperative recurrence of Crohn’s disease: a meta-analysis.
No full textInterferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approach.
No full textShould we cure hepatitis C virus in patients with hepatocellular carcinoma while treating cancer?
No full textDirect acting antivirals (DAAs) stabilize or improve liver function in the majority of patients
with HCV cirrhosis. Hepatic decompensation is the main driver of death of patients with early,
successfully treated HCC superimposed to cirrhosis
. Treatment with DAAs could improve the
prognosis of these subjects, independently from the subsequent course of HCC, if the efficacy in
obtaining viral clearance is as high as in patients without a history of HCC, and if the risk of HCC
recurrence is unaffected
. When dealing with HCC patients, DAA
s can be indicated in two different
settings: a) subjects in which HCC has been already successfully treated (“cured” HCC), or b) subjects
whose HCC is still untreated or untreatable (“active” HCC). While there are abundant data on
“cured” HCC, evidence supporting treatment decisions in patients with “active” HCC is at best scarce
and controversial, since these patients as well as patients with HCC listed for liver transplantation
(LT) are usually excluded from treatment
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
TRASCRITTOMICA COME FRAMEWORK NELLO STUDIO DI NUOVI BIOMARCATORI DI RESISTENZA A STRESS AMBIENTALI: L’ESPERIENZA DI LISTERIA MONOCYTOGENES
No full textListeria monocytogenes is an ubiquitous bacterium responsible of food contamination causing often severe consequences in immunocompromised or pregnant people. The infection is related to the consumption of ready-to-eat food but also fish, meat, dairy and vegetables. Most important, L. monocytogenes often exhibits persistence and resistant features.
In 2015 a severe outbreak occurred in central Italy causing several infected and death people. The responsible strain was identified in “headcheese” samples which, from the point of view of the bacteria, can be considered a stressor environment in terms of storage temperature, pH,
salt and concentration.
Using a transcriptomic approach, based on a differential expression study, we were able to identify key genes and protein modules responsible
of such a fitness. Although expensive and difficult to apply routinely, RNAseq analysis revealed its usefulness in functional characterization of
pathogens strains
Confirmation of crayfish plague in Italy: Detection of Aphanomyces astaci in white clawed crayfish
No full text- …
