1,720,962 research outputs found
Adaptive changes in rat ileum motility induced by mild mesenteric ischemia/reperfusion injury: role of endogenous mediators and reperfusion time
No full textGlutamate receptor activation mediates the effects of ischemia/reperfusion on gastrointestinal transit and neuronal phenotypes in the rat myenteric plexus
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New insights into the pharmacological properties of potent antiplatelet 2-amino-benzo|d|isothiazol-3-one derivatives
No full textUp-regulation of inhibitory transmitters in myenteric neurons of the rat ileum in an acute model of ischemia/reperfusion
No full textRole of Glutamate- N-methyl-D-Aspartate (NMDA) Receptors in Neuronal Plasticity and Gastrointestinal Transit Delay Induced by Ischemia/Reperfusion in Rats
No full textActivation of proteinase-activated receptor 2 prevents gastrointestinal transit delay induced by ischemia/reperfusion in rats
No full textProtective Effects of a Protease Inhibitor (Gabexate Mesilate) on Intestinal Ischemia/Reperfusion Injury in Rats
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Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon “Grosso” essential oil
No full textIn this study the antinociceptive and the gastroprotective effects of orally administered or inhaled Lavandula hybrida Reverchon "Grosso" essential oil, and its principal constituents Linalool and Linalyl acetate were evaluated in rodents. Either when orally administered (100 mg/kg) or inhaled for 60 min lavender essential oil significantly reduced the acetic acid-writhing response in a naloxone-sensitive manner. In hot plate test, analgesic activity observed after oil inhalation was inhibited by naloxone, atropine, mecamylamine pretreatment suggesting the involvement of opioidergic as well as cholinergic pathways. Regardless of the administration route and the experimental model both linalool and linalyi acetate did not produce significant analgesic response. Essential oil oral or inhalatory treatment did not affect mice spontaneous locomotor activity. Concerning the gastric effects, lavender oil, Linalool and Linalyl acetate oral administration protected against acute ethanol-induced gastric ulcers but did not prevent indomethacin-induced lesions indicating no interference with arachidonic acid metabolic cascade. In conclusion, besides this gastroprotection, lavender oil reveals an interesting analgesic activity mainly relevant after inhalation, without sedative side effect, suggesting the interest for potential application of this oil in aromatherapy
Effect of N-methyl-d-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia/reperfusion in rats
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