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Thrombophilic screening in young patients (
No full textThromb Res. 2011 Feb;127(2):85-90. Epub 2010 Dec 18.
Thrombophilic screening in young patients (< 40 years) with idiopathic ischemic
stroke: a controlled study.
Dragoni F, Chiarotti F, Rosano G, Simioni P, Tormene D, Mazzucconi MG, Cafolla A,
Avvisati G.
Thrombosis Center, Department of Biotecnologie Cellulari ed Ematologia,
University Sapienza, Rome, Italy. [email protected]
INTRODUCTION: Despite extensive clinical and laboratory investigations, the
etiology of ischemic stroke remains unknown in approximately one third of
patients.
MATERIALS AND METHODS: Thirty-four consecutive patients less than 40 years old
(Males 13, Females 21, mean age 26.6 years, range 2-39) with documented ischemic
stroke underwent, one year after the acute event, laboratory evaluation of
antithrombin, protein C, free and total protein S, activated protein C
resistance, fibrinogen, factor VII:C, homocysteine levels and antiphospholipid
antibodies (APA). Moreover, prevalence of F5 R506Q, F2 G2021A and homozygosis for
thermolabile variant C677T of the methylenetetrahydrofolate reductase (MTHFR)
were also evaluated and compared to the results obtained in 120 normal controls.
RESULTS: Antithrombin and protein C levels resulted normal in all cases. One
patient (2.9%) showed free protein S deficiency and 3 patients (8.8%) had
activated protein C resistance. Homocysteine levels above 15 μmol/L were found in
one patient (2.9%). APA were found in 21 patients (61.7%) and in only 2 out of
120 (1.66%) controls (OR=95.31; 95% C.I.: 18.22-667.81). The multivariate
analysis selected that the presence of APA was significantly associated with an
increased risk of stroke (OR=156.60; 95% C.I.: 25.99-943.47) in this cohort of
patients. The combination between APA and cardiovascular risk factors determined
a risk of 29-fold (OR=29.31; 95% CI: 3.28-261.69).
DISCUSSION: Our data suggest that the presence of APA is associated with an
increased risk of idiopathic ischemic stroke in young patients. Furthermore, also
the combination of APA and cardiovascular risk factors is significantly
associated with development of idiopathic ischemic stroke.
Copyright © 2010 Elsevier Ltd. All rights reserved.
PMID: 21172722 [PubMed - indexed for MEDLINE
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Thrombophilic screening in young patients (< 40 years) with idiopathic ischemic stroke: a controlled study.
No full text- …
